• Studium der Medizin an der Universität Hamburg
• Promotion (Dr. Med) in der Medizinische Kernklinik am UKE
• Assistenzarzt in der III. Medizinischen Klinik am UKE
• Aufbaustudium „Molekularbiologie“ am Zentrum für Molekulare Neurobiologie Hamburg
• Forschungsstipendium der DFG am Institute for
• Research in Biomedicine in Bellinzona, Schweiz
• Facharzt für Innere Medizin und Facharzt für Nephrologie
• Habilitation in der Inneren Medizin, Universität Hamburg
• Leiter der Klinischen Forschungsgruppe 228 “Immunopathogenesis of GN”
• W3 Professur in der III. Medizinischen Klinik am UKE
• Co-Sprecher des SFB1192
• Leiter der Sektion Translationale Immunologie am UKE

• Franz-Volhard-Preis der Deutschen Gesellschaft für Nephrologie

• Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

  Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol, 2019, accepted

• The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.

  Neumann K, Ostmann A, Breda PC, Ochel A, Tacke F, Paust HJ, Panzer U, Tiegs G Sci Rep. 2019 Feb

• The role of regulatory T cells in Experimental Autoimmune Glomerulonephritis.

  Klinge S, Yan K, Reimers D, Brede KM, Schmid J, Paust HJ, Krebs CF, Panzer U, Hopfer H, Mittrücker H-W. Am J Physiol Renal Physiol. 2019  

• Development and validation of a renal risk score in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

• T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus. 

  Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JEEur J Immunol. 2018 Aug

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

  Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

• Tissue-Resident Lymphocytes in the Kidney. 

  Turner JE, Becker M, Mittrücker HW, Panzer UJ Am Soc Nephrol. 2018 Feb

• Host DNases prevent vascular occlusion by neutrophil extracellular traps.

  Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TAScience. 2017 Dec

• T helper type 17 cells in immune-mediated glomerular disease

  Krebs C, Schmidt T, Riedel J, Panzer U Nat Rev Nephrol. 2017 Oct

• IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

  Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

• An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

  Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

• T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

  Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Ag-gravates the Progression of crescentic glomerulonephritis.

  Gotot J, Piotrowski E, Otte MS, Tittel AP, Guo L, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss FJ Am Soc Nephrol. 2016 Jul

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

  Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

  Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts CJ Am Soc Nephrol. 2016 Nov

• IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

  Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

• RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

  Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

• CXCL5 Drives Neutrophil Recruitment in TH17-Mediated GN
  Disteldorf E, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RAK, Kurts C, Kaufmann SHE, Panzer U.
  J Am Soc Nephrol. 2015

• The immune system and kidney disease: basic concepts and clinical implications.
  Kurts C*, Panzer U*, Anders HJ, Rees AJ*contributed equally
  Nat Rev Immunol. 2013

• Micro-RNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN.
  Krebs CF, Kapffer S, Paust HJ, Schmidt T, Bennstein SB, Peters A, Stege G, Brix SR, Meyer-Schwesinger C, Müller RU, Turner JE, Steinmetz OM, Wolf G, Stahl RA, Panzer U
  J Am Soc Nephrol. 2013

• Immature renal DC recruit regulatory CXCR6+ iNKT cells to attenuate crescentic GN.
  Riedel JH, Paust HJ, Turner JE, Tittel AP, Krebs C, Disteldorf E, Tiegs G, Velden J, Mittrücker HW, Garbi N, Stahl RA, Steinmetz OM, Kurts C, Panzer U
  J Am Soc Nephrol. 2012

• The IL-23 / Th17 axis contributes to renal tissue damage in experimental glomerulonephritis.
  Paust HJ, Turner JE, Steinmetz OM, Peters A, Heymann F, Hölscher C, Wolf G, Kurts C, Mittrücker HW, Stahl RA, Panzer U
  J Am Soc Nephrol. 2009

• Studium der Medizin an der Universität Tübingen
• Promotion (Dr. med.) an der Universität Tübingen
• Arzt im Praktikum im Krankenhaus Siloah, Pforzheim
• Assistenzarzt am Institut für Pathologie an der Universität Tübingen
• Buswell Fellowship und Juniorprofessur in der medizinischen Abteilung, SUNY Buffalo, NY, USA
• Assistenzarzt in der Inneren Medizin an der Universität Freiburg
• Habilitation in der Inneren Medizin an der Universität Freiburg
• Gastwissenschaftler in der Abteilung für Nephrologie an der University of Washington, Seattle, USA
• Außerordentliche Professur der Medizin am Universitätsklinikum Frankfurt am Main
• Professur und Klinikleitung der III. Medizinische Klinik, UKE
• Seniorprofessur an der medizinischen Fakultät an der Universität Hamburg

• Franz-Volhard-Medaille der Deutschen Gesellschaft für Nephrologie (2017)

• Development and validation of a renal risk score in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

• Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

  von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAKFront Immunol. 2018 Dec

• Characterization of Autoantibodies in Primary Membranous Nephropathy and their clinical Significance.

  Stahl RAK, Reinhard L, Hoxha E.Expert Rev Clin Immunol. 2018 Nov

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

  Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

  Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

• IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

  Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

• Immunohistochemical and serological characterization of membranous nephropathy in children and adolescents

  Dettmar A, Wiech T, Kemper M, Soave A, Rink M, Oh J, Stahl R, Hoxha E Pediatr Nephrol. 2018 Mar

• Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

  Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

• A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

  Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

• Translational Aspects of Primary Membranous Nephropathy.

  Hoxha E, Stahl RAK.Semin Nephrol. 2017 Sep

• Membranous nephropathy-one morphologic pattern with different diseases

  Hoxha E, von Haxthausen F, Wiech T, Stahl RPflugers Arch. 2017 Aug

• IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

  Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

• THSD7A expression in human cancer

  Stahl P, Hoxha E, Wiech T, Schröder C, Simon R, Stahl R Genes Chromosomes Cancer. 2017 Apr

• RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

  Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

• An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

  Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

• T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

  Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

  Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

  Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

• Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

  Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

  Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

• RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

  Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

• CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.
  Brix SR, Stege G, Disteldorf E, Hoxha E, Krebs C, Krohn S, Otto B, Klätschke K, Herden E, Heymann F, Lira SA, Tacke F, Wolf G, Busch M, Jabs WJ, Özcan F, Keller F, Beige J, Wagner K, Helmchen U, Noriega M, Wiech T, Panzer U, Stahl RA
  J Am Soc Nephrol. 2015

• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
  Meyer-Schwesinger C, Lambeau G, Stahl RA
  N Engl J Med. 2015

• Studium der Medizin an der Universität Hamburg

• Aufbaustudium „Molekularbiologie“ am Zentrum für Molekulare Neurobiologie Hamburg

• Promotion (Dr. med.) am Institut für Biochemie und Molekulare Biologie, UKE

• Förderung der Werner Otto Stiftung

• Gerok Position in der Klinischen Forschergruppe 228 “Immunopathogenesis and Therapy of Glomerulonephritis”

• Co-Antragsteller für Projekt 6 der KFO 228 “Immunopathogenesis and Therapy of Glomerulonephritis”

• Teilprojektleiter für Projekt B1 des SFB 1191 „Immunvermittelte glomeruläre Erkrankungen - Grundlagen und klinische Auswirkungen„

• Facharzt für Nephrologie und Innere Medizin

• Habilitation in Nephrologie und Innere Medizin

• Else Kröner Exzellenzstipendium

• Oberarzt in der III. Medizinische Klinik, UKE

• Heisenberg-Programm der Deutschen Forschungsgemeinschaft

   

• Leistungsstipendium von der Universität Hamburg (2004)
• „Best abstracts“ von dem XLVII ERA-EDTA Kongress (2010)
• Heinrich Nether Promotionspreis für Molekulare Biologie (2010)
• „Best oral presentations“ Deutschen Gesellschaft für Nephrologie Kongress (2012)
• Nils-Alwall-Preis der Deutschen Gesellschaft für Nephrologie (2016)
• Teacher of the Year 2018

• Bevacizumab-associated glomerular microangiopathy.

  Person F, Rinschen M, Brix S, Wulf S, Noriega M, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz O, Reinhard L, Hoxha E, Zipfel P, Bräsen J, Wiech TMod Pathol. 2018 Dec

• Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

  von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAKFront Immunol. 2018 Dec

• Characterization of Autoantibodies in Primary Membranous Nephropathy and their clinical Significance.

  Stahl RAK, Reinhard L, Hoxha E.Expert Rev Clin Immunol. 2018 Nov

• Genetics of membranous nephropathy.

  Gupta S, Köttgen A, Hoxha E, Brenchley P, Bockenhauer D, Stanescu HC, Kleta R.Nephrol Dial Transplant. 2018 Sep

• The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

  Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

• Immunohistochemical and serological characterization of membranous nephropathy in children and adolescents

  Dettmar A, Wiech T, Kemper M, Soave A, Rink M, Oh J, Stahl R, Hoxha E Pediatr Nephrol. 2018 Mar

• A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

  Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

• Translational Aspects of Primary Membranous Nephropathy.

  Hoxha E, Stahl RAK.Semin Nephrol. 2017 Sep

• Membranous nephropathy-one morphologic pattern with different diseases

  Hoxha E, von Haxthausen F, Wiech T, Stahl RPflugers Arch. 2017 Aug

• THSD7A expression in human cancer

  Stahl P, Hoxha E, Wiech T, Schröder C, Simon R, Stahl R Genes Chromosomes Cancer. 2017 Apr

• An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

  Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

• Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

  Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• Spontaneous remission of proteinuria is a frequent event in phospholipase A2 receptor antibody negative patients with membranous nephropathy.
  Hoxha E, Harendza S, Pinnschmidt HO, Tomas NM, Helmchen U, Panzer U, Stahl RA.
  Nephrol Dial Transplant. 2015

• CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.
  Brix SR, Stege G, Disteldorf E, Hoxha E, Krebs C, Krohn S, Otto B, Klätschke K, Herden E, Heymann F, Lira SA, Tacke F, Wolf G, Busch M, Jabs WJ, Özcan F, Keller F, Beige J, Wagner K, Helmchen U, Noriega M, Wiech T, Panzer U, Stahl RA
  J Am Soc Nephrol. 2015

• PLA2R antibody levels and clinical outcome in patients with membranous nephropathy and non-nephrotic range proteinuria under treatment with inhibitors of the renin-angiotensin system.
  Hoxha E, Harendza S, Pinnschmidt H, Panzer U, Stahl RAK.
  PLoS One. 2014

• Rituximab treatment for relapsing minimal change disease and focal segmental glomerulosclerosis: a systematic review.
  Kronbichler A, Kerschbaum J, Fernandez-Fresnedo G, Hoxha E, Kurschat CE, Busch M, Bruchfeld A, Mayer G, Rudnicki M.
  Am J Nephrol. 2014

• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
  Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
  N Engl J Med. 2014

• M-type phospholipase A2 receptor autoantibodies and renal function in patients with primary membranous nephropathy.
  Hoxha E, Harendza S, Pinnschmidt H, Panzer U, Stahl RA
  Clin J Am Soc Nephrol. 2014

• Phospholipase A2 Receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy.
  Hoxha E, Thiele I, Zahner G, Panzer U, Harendza S, Stahl RA
  J Am Soc Nephrol. 2014

• Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy.
  Dähnrich C, Komorowski L, Probst C, Seitz-Polski B, Esnault V, Wetzels JF, Hofstra JM, Hoxha E, Stahl RA, Lambeau G, Stöcker W, Schlumberger W.
  Clin Chim Acta. 2013

• Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.
  Hoxha E, Kneißler U, Stege G, Zahner G, Thiele I, Panzer U, Harendza S, Helmchen U, Stahl RAK.
  Kidney Int. 2012

• Renal IL-17 expression in human ANCA-associated glomerulonephritis.
  Velden J, Paust HJ, Hoxha E, Turner JE, Steinmetz OM, Wolf G, Jabs WJ, Özcan F, Beige J, Heering PJ, Schröder S, Kneißler U, Disteldorf E, Mittrücker HW, Stahl RA, Helmchen U, Panzer U.
  Am J Physiol Renal Physiol. 2012

• An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis.
  Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl RA
  Nephrol Dial Transplant. 2011

• Rituximab in adult patients with immunosuppressive-dependent minimal change disease.
  Hoxha E, Stahl RAK, Harendza S.
  Clin Nephrol. 2011

• Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
  Meyer-Schwesinger C, Sievert H, Meyer TN, Hoxha E, Sachs M, Klupp E-M, Münster S, Balabanov S, Carrier L, Helmchen U, Thaiss F, Stahl RAK.
  Am J Pathol. 2011

• Posttranscriptional regulation of the p85a adapter subunit of Phosphatidylinositol 3-kinase in human leukemia cells.
  Hoffmann BT, Hoxha E, Mohr E, Schulz K, Jücker M.
  Leuk Lymphoma. 2011

• PLA2R Autoantibodies and recurrent membranous nephropathy after transplantation.
  Stahl RAK, Hoxha E, Fechner K.
  N Engl J Med. 2010

• Studium der Chemie an der Unviersität Frankfurt/Main
• Studium der Biochemie an der Universität Tübingen
• Promotion (Dr. rer. nat.) am Institut für Physiologische Chemie, Universität Tübingen
• Wissenschaftliche Mitarbeiterin in der Abteilung für Biochemische Pharmakologie, Universität Konstanz
• Habilitation in Pharmakologie und Toxikologie, Universität Konstanz
• Professur für Experimentelle Toxikologie am Institut für Experimentelle und Klinische Pharmakologie der Medizinischen Fakultät der Universität Erlangen-Nürnberg
• Professur und Leitung des Instituts für Experimentelle Immunologie und Hepatologie, UKE
• Leitung der Pharmakologie und Toxikologie an der Universität Regensburg, abgelehnt

• Hans Popper “Förderpreis” für die beste experimentelle Arbeit mit klinischem Bezug auf dem Gebiet der Hepatologie
• Sandoz-Preis für therapierelevante pharmakologische Forschung

• The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.

  Neumann K, Ostmann A, Breda PC, Ochel A, Tacke F, Paust HJ, Panzer U, Tiegs G Sci Rep. 2019 Feb

• IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

  Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

• RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

  Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

• T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

  Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

  Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

• Deletion of tumour necrosis factor α receptor 1 elicits an increased TH17 immune response in the chronically inflamed liver.
  Berkhout L, Barikbin R, Schiller B, Ravichandran G, Krech T, Neumann K, Sass G, Tiegs G
  Sci Rep. 2019

• Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice.
  Horst AK*, Wegscheid C*, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert AE, Oldhafer KJ, Weiler-Normann C, Lang KS, Singer BB, Altfeld M, Diehl L, Tiegs G
  Hepatology. 2018

• A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis.
  Neumann K*, Karimi K*, Meiners J, Voetlause R, Steinmann S, Dammermann W, Lüth S, Asghari F, Wegscheid C, Horst A, Tiegs G
  J Immunol. 2017

• Regulatory T cell-derived interleukin-10 ameliorates crescentic glomerulonephritis.
  Ostmann A, Paust HJ, Panzer U, Wegscheid C, Kapffer S, Huber S, Flavell RA, Erhardt A, Tiegs G
  J Am Soc Nephrol. 2013

• Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
  Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
  J Immunol. 2013

• Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
  Paust HJ, Ostmann A, Erhardt A, Turner JE, Velden J, Mittrücker HW, Sparwasser T, Panzer U, Tiegs G.
  Kidney Int. 2011

• CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis.
  Erhardt A, Wegscheid C, Claass B, Carambia A, Herkel J, Mittrücker HW, Panzer U, Tiegs G
  J Immunol. 2011

• Autonomic renal denervation ameliorates experimental GN.
  Veelken R, Vogel EM, Hilgers K, Amann K, Hartner A, Sass G, Neuhuber W, Tiegs G
  J Am Soc Nephrol. 2008

• Studium der Medizin an der Universität Witten/Herdecke
• Promotion (Dr. med.) am Institut für Immunologie, Universität Witten/Herdecke; summa cum laude
• United states medical licensing examination (USMLE)
• Assistenzarzt in der III. Medizinische Klinik, UKE
• Gerok Position in der Klinischen Forschungsgruppe 228 “Immunopathogenesis and Therapy of Glomerulonephritis”
• Postdoctoral fellowship am Institut für Molekulare und Zelluläre Pharmakologie, Universität Nizza / Sophia Antipolis, Frankreich
• Projektleiter der Emmy Noether Forschungsgruppe “Molecular Mechanisms of Membranous Nephropathy”

• Dr.-Martini-Preis der Dr.-Martini-Stiftung in Hamburg (2017)

• The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

  Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

• A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

  Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

• An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

  Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

• Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

  Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
  Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
  N Engl J Med. 2014

• Akt and phospholipase Cγ are involved in the regulation of growth and migration of MDA-MB-468 breast cancer and SW480 colon cancer cells when cultured with diabetogenic levels of glucose and insulin.
  Tomas, NM, Masur, K, Piecha, JC, Niggemann, B, Zanker, KS
  BMC Res Notes. 2012

• Studium der Biologie an der Universität Stuttgart
• Promotion (Dr. rer. Nat.) in der Nephrologie an der Universität Frankfurt
• Postdoc und Laborleiter in der III. Medizinischen Klinik, UKE
• Habilitation in Experimenteller Medizin an der Universität Hamburg

• The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

  Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

• A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

  Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

• An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

  Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

• Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

  Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
  Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
  N Engl J Med. 2014

• Phospholipase A2 Receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy.
  Hoxha E, Thiele I, Zahner G, Panzer U, Harendza S, Stahl RA
  J Am Soc Nephrol. 2014
  
  
• Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis.
  Kluger MA, Zahner G, Paust HJ, Schaper M, Magnus T, Panzer U, Stahl RA
  Kidney Int. 2013
  
  
• Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.
  Hoxha E, Kneißler U, Stege G, Zahner G, Thiele I, Panzer U, Harendza S, Helmchen UM, Stahl RA
  Kidney Int. 2012
  
  
• An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis.
  Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl RA
  Nephrol Dial Transplant. 2011
  
  
• Prostaglandin EP2 and EP4 receptors modulate expression of the chemokine CCL2 (MCP-1) in response to LPS-induced renal glomerular inflammation.
  Zahner G, Schaper M, Panzer U, Kluger M, Stahl RA, Thaiss F, Schneider A
  Biochem J. 2009
  
  
• 15-Deoxy-∆12,14-prostaglandin J2 inhibits INF-gamma- induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells.
  Panzer U*, Zahner G*, Wienberg U, Steinmetz OM, Peters A, Turner JE, Paust HJ,
  Wolf G, Stahl RA, Schneider A *contributed equally
  Nephrol Dial Transplant. 2008
  
  
• Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell
  proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase
  inhibitors p21waf/cip-1 and p27kip-1.
  Zahner G, Wolf G, Ayoub M, Reinking R, Panzer U, Shankland SJ, Stahl RA
  J Biol Chem. 2002
  
  
• Prostaglandin E2 stimulates expression of matrix metalloproteinase 2 in cultured rat mesangial cells.
  Zahner G, Harendza S, Müller E, Wolf G, Thaiss F, Stahl RA
  Kidney Int. 1997

• Studium der Medizin an der Universität Köln und Universität Hamburg
• Promotion (Dr. med.) im Zentrum für Molekulare Neurobiologie Hamburg (ZMNH)
• Assistenzarzt in der III. Medizinischen Klinik, UKE
• Postdoc am Centre for Inflammatory Diseases, Monash, Australia
• Facharzt für Innere Medizin und Nephrologie
• Habilitation in Innere Medizin an der Universität Hamburg
• Oberarzt in der III. Medizinische Klinik, UKE
• aPL Professur

• Hans-U.-Zollinger-Forschungspreis der DGfN (2015)
• Dr.-Liselotte-Brauns-Preis für Innere Medizin der Liselotte-Brauns Stiftung (2015)

• Bevacizumab-associated glomerular microangiopathy.

  Person F, Rinschen M, Brix S, Wulf S, Noriega M, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz O, Reinhard L, Hoxha E, Zipfel P, Bräsen J, Wiech TMod Pathol. 2018 Dec

• Lupusnephritis

  Melderis S, Wiech T, Iking-Konert C, Steinmetz OZ Rheumatol. 2018 Sep

• IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

  Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

  Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

• RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

  Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

• T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

  Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

• CD4+ T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes.

  Krebs CF, Steinmetz OM.Mediators Inflamm. 2016

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

  Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

  Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

• RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

  Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
  Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
  Kidney Int. 2016
  
  
• RORγt+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN
  Kluger M, Meyer M, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
  J Am Soc Nephrol. 2016
  
  
• Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
  Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RAK, Panzer U, Steinmetz OM:
  J Am Soc Nephrol. 2015
  
  
• Stat3 Programs Th17-Specific Regulatory T Cells to Control GN.
  Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix S, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM
  J Am Soc Nephrol. 2014

• B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis.
  Kluger MA, Ostmann A, Luig M, Meyer MC, Goerke B, Paust HJ, Meyer-Schwesinger C, Stahl RA, Panzer U, Tiegs G, Steinmetz OM
  Eur J Immunol. 2014
  
  
• Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
  Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B
  Nat Immunol. 2013
  
  
• The Th17-defining transcription factor RORγt promotes glomerulonephritis.
  Steinmetz OM, Summers SA, Gan PY, Semple T, Holdsworth SR, Kitching AR
  J Am Soc Nephrol. 2011

• Studium der Medizin an der Universität Hamburg
• Promotion (Dr. Med.) in der III. Medizinischen Klinik, UKE
• Assistenzarzt in der III. Medizinischen Klinik, UKE
• Forschungsstipendium der Medizinischen Fakultät am UKE (FFM-Programm)
• DAAD-geförderter Forschungsaufenthalt im Center for Inflammatory Diseases in Melbourne/Australia
• Facharzt für Innere Medizin und Nephrologie
  Clinician Scientist Programm, UKE
• Habilitation in Innere Medizin/Nephrologie, Universität Hamburg
• Stipendium der Deutschen Gesellschaft für Nephrologie und Deutschen Nierenstiftung
• Oberarzt in der III. Medizinischen Klinik, UKE
• Forschungskoordinator des Universitären Transplantations Centrums (UTC), UKE

• IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

  Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

• RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

  Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

• T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

  Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

• IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

  Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

• RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

  Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
  Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
  Kidney Int. 2016
  
  
• RORγt+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN
  Kluger M, Meyer M, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
  J Am Soc Nephrol. 2016
  
  
• Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
  Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RAK, Panzer U, Steinmetz OM:
  J Am Soc Nephrol. 2015
  
  
• Stat3 Programs Th17-Specific Regulatory T Cells to Control GN.
  Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix S, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM
  J Am Soc Nephrol. 2014
  

• B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis.
  Kluger MA, Ostmann A, Luig M, Meyer MC, Goerke B, Paust HJ, Meyer-Schwesinger C, Stahl RA, Panzer U, Tiegs G, Steinmetz OM
  Eur J Immunol. 2014

• Studium der Medizin an der Universität Freiburg
• Promotion (Dr. med) an der Universität Freiburg und der Harvard Medical School, Boston, USA; summa cum laude
• Post-Doc-Stipendiatin am department of nephrology an der University of California, San Diego
• Wissenschaftliche Mitarbeiterin in der III. Medizinischen Klinik, UKE
• Habilitation in Experimenteller Medizin an der Universität Hamburg
• Heisenberg Stipendium
• W3 Heisenberg Professur Institut für Zelluläre und Integrative Physiologie, UKE Hamburg

• Dr. Martinipreis, UKE Hamburg-Eppendorf

• Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.

  Reinicke, AT, Laban, K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch CP, Duncan KE, Saftig P, Rischen MM, Morellini F, Meyer-Schwesinger CProc Natl Acad Sci U S A. 2019 Mar

• Thrombospondin type 1 domain-containing 7A (THSD7A) localizes to the slit diaphragm and stabilizes membrane dynamics of fully differentiated podocytes

  Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger CJASN, 2019, accepted

• The Ubiquitin Proteasome System in Kidney Physiology and Pathophysiology 

  Meyer-Schwesinger CNat Rev Nephrol 2019 in press

• Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

  Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol, 2019, accepted

• Protecting the kidney against autoimmunity and inflammation.

  Christian Kurts, Catherine Meyer-SchwesingerNat Rev Nephrol. 2018 Dec

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

  Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

• A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

  Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

• IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

  Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

• An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

  Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

• Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. 

  Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte FSci Transl Med. 2016 Nov

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

  Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

  Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• The Role of Renal Progenitors in Renal Regeneration

  Meyer-Schwesinger C Nephron. 2016

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
  Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
  Kidney Int. 2016
  
  
• The Role of Renal Progenitors in Renal Regeneration
  Meyer-Schwesinger C
  Nephron. 2016
  
  
• MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype.
  Kietzmann L*, Guhr SS*, Meyer TN, Ni L, Sachs M, Panzer U, Stahl RA, Saleem MA, Kerjaschki D, Gebeshuber CA* and Meyer-Schwesinger C*. *contributed equally
  J Am Soc Nephrol. 2015
  
  
• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
  Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
  N Engl J Med. 2014
  
  
• UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.
  Lohmann F, Sachs M, Meyer TN, Sievert H, Lindenmeyer MT, Wiech T, Cohen CD, Balabanov S, Stahl RAK, Meyer-Schwesinger C
  Biochim Biophys Acta. 2014
  
  
• Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases.
  Beeken M*, Lindenmeyer MT*, Blattner SM*, Radón V*, Oh J, Meyer TN, Hildebrand D, Schlüter H, Reinicke AT, Knop JH, Vivekanandan-Giri A, Münster S, Sachs M, Wiech T, Pennathur S, Cohen CD, Kretzler M, Stahl RAK, Meyer-Schwesinger C. *contributed equally
  J Am Soc Nephrol. 2014
  
  
• Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium.
  Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ, Garbi N, Kastenmüller W, Knolle PA, Kurts C*, Engel DR*. *contributed equally
  Cell. 2014
  
  
• The expression of podocyte-specific proteins in parietal epithelial cells is regulated by protein degradation.
  Guhr SS, Sachs M, Wegner A, Becker JU, Meyer TN, Kietzmann L, Schlossarek S, Carrier L, Braig M, Jat PS, Stahl RA, Meyer-Schwesinger C.
  Kidney Int. 2013

• Studium der Biologie an der Universität Mainz
• Promotion (Dr. rer. nat.) in der 1. Medizinischen Klinik, Sektion Pathophysiologie, Universität Mainz
• Postdoc in der Abteilung Immunolgie am Bernhard-Nocht-Institute für Tropenmedizin, Hamburg
• Postdoc am Ontario Cancer Institute, Toronto, Canada
• Arbeitsgruppenleiter in der Abteilung Immunologie am Max-Planck-Institute für Infektionsbiologie, Berlin
• Habilitation in Immunologie und Medizinischer Mikrobiologie an der Freien Universität Berlin
• W2 Professur am Institut für Immunologie, UKE Hamburg

• The role of regulatory T cells in Experimental Autoimmune Glomerulonephritis.

  Klinge S, Yan K, Reimers D, Brede KM, Schmid J, Paust HJ, Krebs CF, Panzer U, Hopfer H, Mittrücker H-W. Am J Physiol Renal Physiol. 2019  

• Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice.

  Rosendahl A, Kabiri R, Bode M, Cai A, Klinge S, Ehmke H, Mittrücker HW, Wenzel UOBr J Pharmacol. 2018 Sep

• Tissue-Resident Lymphocytes in the Kidney. 

  Turner JE, Becker M, Mittrücker HW, Panzer UJ Am Soc Nephrol. 2018 Feb

• Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling.

  Dixit A, Bottek J, Beerlage AL, Schuettpelz J, Thiebes S, Brenzel A, Garbers C, Rose-John S, Mittrücker H-W, Squire A, Engel DR.J Leukoc Biol. 2018 Jan

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism.
  Mahnke J, Schumacher V, Ahrens S, Käding N, Feldhoff LM, Huber M, Rupp J, Raczkowski F, Mittrücker H-W
  Sci Rep. 2016
  
  
• ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.
  Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker H-W*, Chalaris A*. *contributed equally
  J Leukoc Biol. 2016
  
  
• CXCR3+ regulatory T cells control TH1 responses in crescentic GN.
  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H-W, Steinmetz OM, Stahl RA, Panzer U.
  J Am Soc Nephrol. 2016
  
  
• TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis.
  Hünemörder S, Treder J, Ahrens S, Schumacher V, Paust HJ, Menter T, Matthys P, Kamradt T, Meyer-Schwesinger C, Panzer U, Hopfer H, Mittrücker H-W (2015).
  J Pathol. 2015
  
  
• Glomerulopathy induced by immunization with a peptide derived from the Goodpasture antigen α3IV-NC1.
  Hopfer H, Hünemörder S, Treder J, Turner J-E, Paust H-J, Meyer-Schwesinger C, Hopfer U, Sachs M, Peters A, Bucher-Kocaoglu B, Ahrens S, Panzer U, Mittrücker H-W (2015).
  J Immunol. 2015
  
  
• CXCL5 drives neutrophil recruitment in TH17-mediated GN.
  Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U.
  J Am Soc Nephrol. 2015
  
  
• The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
  Raczkowski F, Ritter J, Heesch K, Schumacher V, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker H-W*, Huber M*. (*contributed equally)
  Proc Natl Acad Sci U S A. 2013
  
  
• Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis.
  Hopfer H, Holzer J, Hünemörder S, Paust HJ, Sachs M, Meyer-Schwesinger C, Turner JE, Panzer U, Mittrücker H-W
  Kidney Int. 2012

• Studium der Medizin an den Universitäten Göttingen und Hamburg
• Promotion (Dr. med.) am Institut für Immunologie, UKE; summa cum laude
• Facharzt für Innere Medizin und Nephrologie
  Forschungsstipendium der Medizinischen Fakultät am UKE
• Stipendium der Deutschen Gesellschaft für Nephrologie und Deutschen Nierenstiftung
• Habilitation in Innere Medizin und Nephrologie an der Universität Hamburg
• Oberarzt in der III. Medizinische Klinik, Sektion Translationale Immunologie, UKE

• Medac-Forschungspreis für Immunologie (Promotion) (2006)
• Adalbert-Buding-Forschungspreis der Deutschen Hochdruckliga (2011)
• Dr.-Martini-Preis der Dr.-Martini-Stiftung in Hamburg (2014)
• Hans-U.-Zollinger-Forschungspreis der DGfN (2017)

• The role of regulatory T cells in Experimental Autoimmune Glomerulonephritis.

  Klinge S, Yan K, Reimers D, Brede KM, Schmid J, Paust HJ, Krebs CF, Panzer U, Hopfer H, Mittrücker H-W. Am J Physiol Renal Physiol. 2019  

• Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

  Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson J, Antonson P, Roncarolo M, Villablanca E, Gagliani N, Huber SNat Commun. 2018 Dec

• IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

  Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

• T helper type 17 cells in immune-mediated glomerular disease

  Krebs C, Schmidt T, Riedel J, Panzer U Nat Rev Nephrol. 2017 Oct

• IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.

  Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S.J Immunol. 2017 Feb

• CD4+ T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes.

  Krebs CF, Steinmetz OM.Mediators Inflamm. 2016

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

  Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

• IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

  Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

• Immune Mechanisms in Arterial Hypertension

  Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

• CXCL5 drives neutrophil recruitment in TH17-mediated GN.
  Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U.
  J Am Soc Nephrol. 2015
  
  
• Micro-RNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN.
  Krebs CF, Kapffer S, Paust HJ, Schmidt T, Bennstein SB, Peters A, Stege G, Brix SR, Meyer-Schwesinger C, Müller RU, Turner JE, Steinmetz OM, Wolf G, Stahl RA, Panzer U
  J Am Soc Nephrol. 2013
  
  
• Immature renal DC recruit regulatory CXCR6+ iNKT cells to attenuate crescentic GN.
  Riedel JH, Paust HJ, Turner JE, Tittel AP, Krebs C, Disteldorf E, Tiegs G, Velden J, Mittrücker HW, Garbi N, Stahl RA, Steinmetz OM, Kurts C, Panzer U
  J Am Soc Nephrol. 2012
  
  
• CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.
  Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F.
  J Immunol. 2005
  
  
• NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.
  Seman M, Adriouch S, Scheuplein F, Krebs C, Freese D, Glowacki G, Deterre P, Haag F, Koch-Nolte F.
  Immunity. 2003

• Studium der Medizin an der Universität Ulm, Heidelberg, und Mainz
• Promotion (Dr. med.) in der I. Medizinische Klinik, Universität Mainz
• Assistenzarzt in der I. Medizinische Klinik, UKE
• Postdoc am Department of Immunobiology, Yale University, School of Medicine
• Leiter einer Forschungsgruppe in der I. Medizinische Klinik, UKE
• Peter Hans Hofschneider Professor (W2) für Molekulare Immunologie und Gastroenterologie in der I. Medizinischen Klinik, UKE
• Oberarzt in der I. Medizinischen Klinik, UKE
• Heisenberg Professor (W3) für Intestinale Immunregulation

• Dr.-Martini-Preis der Dr.-Martini-Stiftung (2009)
• Postdoctoral research fellowship award der
• Crohns and Colitis foundation of America (2011)
• Ernst Jung-Karriere-Förderpreis (2012)
• Dr.-Liselotte-Brauns-Preis der Liselotte-Brauns Stiftung (2013)
• Theodor-Frerichs-Preis der Deutschen Gesellschaft für Innere Medizin (DGIM) (2017)

• Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

  Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol, 2019, accepted

• Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

  Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson J, Antonson P, Roncarolo M, Villablanca E, Gagliani N, Huber SNat Commun. 2018 Dec

• IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

  Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

• IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.

  Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S.J Immunol. 2017 Feb

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

  Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

• A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.
  Pelczar, P., M. Witkowski, L. G. Perez, J. Kempski, A. G. Hammel, L. Brockmann, D. Kleinschmidt, S. Wende, C. Haueis, T. Bedke, M. Witkowski, S. Krasemann, S. Steurer, C. J. Booth, P. Busch, A. Konig, U. Rauch, D. Benten, J. R. Izbicki, T. Rosch, A. W. Lohse, T. Strowig, N. Gagliani*, R. A. Flavell*, and S. Huber*. *contributed equally
  Science. 2016
  
  
• Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
  Gagliani, N., M. C. Amezcua Vesely, A. Iseppon, L. Brockmann, H. Xu, N. W. Palm, M. R. de Zoete, P. Licona-Limon, R. S. Paiva, T. Ching, C. Weaver, X. Zi, X. Pan, R. Fan, L. X. Garmire, M. J. Cotton, Y. Drier, B. Bernstein, J. Geginat, B. Stockinger, E. Esplugues, S. Huber*, and R. A. Flavell*. *contributed equally
  Nature. 2015
  
  
• Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.
  Gagliani N*, Magnani CF*, Huber S*, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A, Trentini F, Di Serio C, Bacchetta R, Andreani M, Brockmann L, Gregori S, Flavell RA, Roncarolo MG. *contributed equally
  Nat Med. 2013
  
  
• IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
  Huber S*, Gagliani N*, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O’Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA *contributed equally
  Nature. 2012
  
  
• Control of TH17 cells occurs in the small intestine.
  Esplugues E*, Huber S*, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor WJr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. *contributed equally
  Nature. 2011
  
  
• Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
  Huber S*, Gagliani N*, Esplugues E*, O'Connor WJr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. *contributed equally
  Immunity. 2011

• Studium der Biologie an den Universitäten in Lehigh und Wesleyan, USA
• Bachelor of Arts in Biologie an der Universität Wesleyan, USA
• Studium der Medizin an der Universität Hamburg und Tübingen
• Promotion (Dr. med.) an der Universität Tübingen
• Studium der Molekularen Biologie an der Universität Hamburg
• Habilitation und venia legendi in Immunologie und Molekulare Biologie, UKE
• Forschungsaufenthalt im The Jackson Lab, Bar Harbor, ME
• Forschungsaufenthalt an der University of California in San Francisco, CA
• Professur für Immunologie and Molekulare Biologie, Universität Hamburg
• Forschungsaufenthalt am DNAX Research Institute, Palo Alto, CA
• Forschungsaufenthalt im The Jackson Lab, Bar Harbor, ME
• Stellvertretender Direktor am Institut für Immunologie, UKE
• Forschungsaufenthalt an der Université Rouen, France

• Martini-Preis (1990)
• Preis der Werner-Otto-Stiftung (1999)
• Preis für Mentorship der Claussen-Simon Stiftung (2009)

• Purine Release, Metabolism, and Signaling in the Inflammatory Response.

  Linden J, Koch-Nolte F, Dahl G.Annu Rev Immunol. 2019 Jan

• T RM maintenance is regulated by tissue damage via P2RX7.

  Stark R, Wesselink TH, Behr FM, Kragten NAM, Arens R, Koch-Nolte F, van Gisbergen KPJM, van Lier RAW.Sci Immunol. 2018 Dec

• CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.

  Schütze K, Petry K, Hambach J, Schuster N, Fumey W, Schriewer L, Röckendorf J, Menzel S, Albrecht B, Haag F, Stortelers C, Bannas P, Koch-Nolte F.Front Immunol. 2018 Nov

• Monitoring the Sensitivity of T Cell Populations Towards NAD+ Released During Cell Preparation.

  Rissiek B, Lukowiak M, Haag F, Magnus T, Koch-Nolte F.Methods Mol Biol. 2018 Aug    

• Modulating ion channel function with antibodies and nanobodies.

  Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F.Curr Opin Immunol. 2018 Jun

• The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

  Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

• Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity.

  Menzel S, Schwarz N, Haag F, Koch-Nolte F.Front Pharmacol. 2018 Mar

• A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

  Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

• Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. 

  Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte FSci Transl Med. 2016 Nov

• Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

  Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

• Trm maintenance is regulated by tissue damage via P2RX7.
  Stark R, Wesselink TH, Behr FM, Kragten NAM, Arens R, Koch-Nolte F, van Gisbergen KPJM, van Lier RAW
  Sci Immunol. 2018
  
  
• Modulating ion channel function with antibodies and nanobodies.
  Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F.
  Curr Opin Immunol. 2018
  
  
• A cDNA immunization strategy to generate nanobodies against membrane proteins in native conformation.
  Eden T, Menzel S, Wesolowski J, Bergmann P, Nissen M, Dubberke G, Seyfried F, Albrecht B, Haag F, Koch-Nolte F.
  Front Immunol. 2018
  
  
• Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.
  Fumey W, Koenigsdorf J, Kunick V, Menzel S, Schütze K, Unger M, Schriewer L, Haag F, Adam G, Oberle A, Binder M, Fliegert R, Guse A, Zhao YJ, Cheung Lee H, Malavasi F, Goldbaum F, van Hegelsom R, Stortelers C, Bannas P, Koch-Nolte F
  Sci Rep. 2017
  
  
• NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells.
  Scheuplein F, Schwarz N, Adriouch S, Krebs C, Bannas P, Rissiek B, Seman M, Haag F, Koch-Nolte F
  J Immunol. 2009
  
  
• NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.
  Seman M, Adriouch S, Scheuplein F, Krebs C, Freese D, Glowacki G, Deterre P, Haag F, Koch-Nolte F.
  Immunity. 2003

• Studium der Medizin an der Universität Göttingen
• Promotion (Dr. med.) am European Neuroscience Institute Göttingen
• Assistenzarzt in der III. Medizinischen Klinik, UKE
• Forschungsstipendium der DFG am MRC National Institute for Medical Research, London
• Facharzt für Innere Medizin und Nephrologie
• Projektleiter des DFG geförderten Emmy-Noether-Froschungsgruppe “Innate Lymphoid Cells in Renal Inflammation”
• Habilitation und Lehrberechtigung in der Inneren Medizin und Nephrologie
• Oberarzt in der III. Medizinischen Klinik, UKE

• Walter-Hörl-Stipendium der Deutschen Nierenstiftung (2013)
• Hans-U.-Zollinger-Forschungspreis der DGfN (2018)

• Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

  Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol, 2019, accepted

• T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus. 

  Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JEEur J Immunol. 2018 Aug

• Innate lymphoid cells in autoimmunity and chronic inflammatory diseases. 

  Xiong T, Turner JESemin Immunopathol. 2018 Jul

• Innate Lymphoid Cells – Key players in tissue-specific immunity. 

  Turner JE, Gasteiger GSemin Immunopathol. 2018 Jul

• IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

  Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

• Tissue-Resident Lymphocytes in the Kidney. 

  Turner JE, Becker M, Mittrücker HW, Panzer UJ Am Soc Nephrol. 2018 Feb

• Natural killers: the bad guys in fibrosis? 

  Turner JEKidney Int. 2017 Jul

• IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

  Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

  Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

• IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

  Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

• Immune Mechanisms in Arterial Hypertension

  Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

• IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation.
  Turner JE, Morrison PJ, Wilhelm C, Wilson M, Ahlfors H, Renauld JC, Panzer U, Helmby H, Stockinger B
  J Exp Med. 2013
  
  
• Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
  Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B
  Nat Immunol. 2013
  
  
• IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection.
  Turner JE, Stockinger B, Helmby H
  PLoS Pathog. 2013
  
  
• IL-17A production by renal gd T cells promotes kidney injury in crescentic GN.
  Turner JE, Krebs C, Tittel AP, Paust HJ, Meyer-Schwesinger C, Bennstein SB, Steinmetz OM, Prinz I, Magnus T, Korn T, Stahl RA, Kurts C, Panzer U
  J Am Soc Nephrol. 2012
  
  
• CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis.
  Turner JE, Paust HJ, Steinmetz OM, Peters A, Riedel JH, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrucker HW, Tiegs G, Stahl RA, Panzer U
  J Am Soc Nephrol. 2010
  
  
• The many lives of IL-9: a question of survival?
  Wilhelm C, Turner JE, Van Snick J, Stockinger B
  Nat Immunol. 2012
  
  
• The Th17 immune response in renal inflammation.
  Turner JE, Paust HJ, Steinmetz OM, Panzer U
  Kidney Int. 2010

• Studium der Medizin an der Universität Hamburg
• Promotion (Dr. med.) in der Medizinischen Kernklinik am UKE
• Assistenzarzt am Institut für Pathologie in Freiburg
• Weiterbildung in Nierenpathologie am Institut für Pathologie in Basel
• Facharzt in Pathologie
• Habilitation in Pathologie an der Universität Freiburg
• Oberarzt am Institut für Pathologie am UKE
• W2 Professur am Institut für Pathologie am UKE

• Michael J. Mihatsch & Dusan Ferluga Award der Europäischen Gesellschaft für Pathologie

• Bevacizumab-associated glomerular microangiopathy.

  Person F, Rinschen M, Brix S, Wulf S, Noriega M, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz O, Reinhard L, Hoxha E, Zipfel P, Bräsen J, Wiech TMod Pathol. 2018 Dec

• Development and validation of a renal risk score in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

• Potential role for urine PCR in the diagnosis of Whipple's disease.

  Moter A, Janneck M, Wolters M, Iking-Konert C, Wiessner A, Loddenkemper C, Hartleben B, Lütgehetmann M, Schmidt J, Langbehn U, Janssen S, Geelhaar-Karsch A, Schneider T, Moos V, Rohde H, Kikhney J, Wiech T.Clin Infect Dis. 2018 Oct

• Lupusnephritis

  Melderis S, Wiech T, Iking-Konert C, Steinmetz OZ Rheumatol. 2018 Sep

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

  Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PFJ Immunol. 2018 Apr

• Immunohistochemical and serological characterization of membranous nephropathy in children and adolescents

  Dettmar A, Wiech T, Kemper M, Soave A, Rink M, Oh J, Stahl R, Hoxha E Pediatr Nephrol. 2018 Mar

• Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

  Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

• Membranous nephropathy-one morphologic pattern with different diseases

  Hoxha E, von Haxthausen F, Wiech T, Stahl RPflugers Arch. 2017 Aug

• THSD7A expression in human cancer

  Stahl P, Hoxha E, Wiech T, Schröder C, Simon R, Stahl R Genes Chromosomes Cancer. 2017 Apr

• An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

  Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• CXCR3+ regulatory T cells control TH1 responses in crescentic GN.
  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H-W, Steinmetz OM, Stahl RA, Panzer U.
  J Am Soc Nephrol. 2016
  

• FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.
  Zhou W, Otto EA, Cluckey A, Airik R, Hurd TW, Chaki M, Diaz K, Lach FP, Bennett GR, Gee HY, Ghosh AK, Natarajan S, Thongthip S, Veturi U, Allen SJ, Janssen S, Ramaswami G, Dixon J, Burkhalter F, Spoendlin M, Moch H, Mihatsch MJ, Verine J, Reade R, Soliman H, Godin M, Kiss D, Monga G, Mazzucco G, Amann K, Artunc F, Newland RC, Wiech T, Zschiedrich S, Huber TB, Friedl A, Slaats GG, Joles JA, Goldschmeding R, Washburn J, Giles RH, Levy S, Smogorzewska A, Hildebrandt F.
  Nat Genet. 2012
  
  
• Histopathological patterns of nephrocalcinosis: a phosphate type can be distinguished from a calcium type.
  Wiech T, Hopfer H, Gaspert A, Banyai-Falger S, Hausberg M, Schröder J, Werner M, Mihatsch MJ.
  Nephrol Dial Transplant. 2012

• Studium der Biologie an der Universität Würzburg
• Promotion (Dr. rer. nat.) am Max Planck Institut für Infektionsbiologie, Berlin
• DFG Stipendium am Immune Disease Institute an der Harvard Medical School
• Post-Doc-Stipendium am Immune Disease Institute an der Harvard Medical School
• Dozent am Immune Disease Institute an der Harvard Medical School
• Arbeitsgruppenleiter am Universitätsklinikum Hamburg-Eppendorf
• Marie Curie Stipendium am Universitätsklinikum Hamburg Eppendorf

• Young Talent Award der Gesellschaft für Thrombose- und Hämostaseforschung
• Alexander Schmidt Award der Gesellschaft für Thrombose- und Hämostaseforschung

• Host DNases prevent vascular occlusion by neutrophil extracellular traps.

  Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TAScience. 2017 Dec

• Neutrophil Extracellular Traps.
  Fuchs TA, Hakkim AR, Urban CF.
  Inflammation – Fundamental Mechanisms. Ed. Klaus Ley. 2018; Chapter 6: 205-76

• Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism.
  Jiménez-Alcázar M*, Limacher A*, Panda R, Méan M, Bitterling J, Peine S, Renné T, Beer JH, Aujesky D, Lämmle B, Fuchs TA.
  PLoS One. 2018
  
  
• Therapeutic targeting of extracellular DNA improves the outcome of intestinal infarction in neonatal rats.
  Boettcher M, Eschenburg G, Mietzsch S, Jiménez-Alcázar M, Klinke M, Vincent D, Tiemann B, Bergholz R, Reinshagen K, Fuchs TA.
  Sci Rep. 2017
  
  
• Neutrophil extracellular traps contain selected antigens of anti-neutrophil cytoplasmic antibodies.
  Panda R, Krieger T, Hopf L, Renné T, Haag F, Röber N, Condrad K, Csernok E, Fuchs TA.
  Front Immunol. 2017
  
  
• Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies
  Jiménez-Alcázar M, Napirei M, Panda R, Köhler EC, Kremer-Hovinga JA, Mannherz HG, Peine S, Renné T, Lämmle B, Fuchs TA.
  J Thromb Haemost. 2015
  
  
• Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic Cicroangiopathies
  Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lämmle B.
  Blood. 2012
  
  
• Histones induce rapid and profound thrombocytopenia in mice
  Fuchs TA, Bhandari AA, Wagner DD.
  Blood. 2011
  
  
• Extracellular DNA traps promote thrombosis.
  Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD Jr, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD.
  Proc Natl Acad Sci U S A. 2010
  
  
• Novel cell death program leads to neutrophil extracellular traps
  Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, Weinrauch Y, Brinkmann V,
  Zychlinsky A.
  J Cell Biol. 2007

• Studium der Medizin an der Universität Berlin
• Promotion (Dr. Med) am Klinikum Steglitz, Universität Berlin
• Assistenzarzt in der Medizinischen Klinik an der Universität Frankfurt und im Verlauf in der III. Medizinischen Klinik am UKE
• Forschungsstipendium (Post-Doc) der DFG am Health Science Center in San Antonio, USA
• Facharzt für Innere Medizin und Facharzt für Nephrologie
• Habilitation in der Inneren Medizin, Universität Hamburg
• Oberarzt in der III. Medizinischen Klinik am UKE
• Professur in der III. Medizinischen Klinik am UKE
• Stellvertretender Direktor der Medizinischen Klinik I am Krankenhaus Herne, Universität Bochum (2010-2011)

• Franz-Gross-Wissenschaftspreis Deutsche Hochdruckliga

• Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice.

  Rosendahl A, Kabiri R, Bode M, Cai A, Klinge S, Ehmke H, Mittrücker HW, Wenzel UOBr J Pharmacol. 2018 Sep

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Salt, inflammation, IL-17 and hypertension.

  Wenzel UO, Bode M, Kurts C, Ehmke H.Br J Pharmacol. 2018 May

• Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

  Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

• A pathogenic role of complement in arterial hypertension and hypertensive end organ damage.

  Wenzel UO, Bode M, Köhl J, Ehmke HAm J Physiol Heart Circ Physiol. 2017 Mar

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

  Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• Immune Mechanisms in Arterial Hypertension

  Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

• Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate and angiotensin II-induced hypertension.
  Krebs CF, Lange S, Niemann G, Rosendahl A, Lehners A, Meyer-Schwesinger C, Stahl RA, Benndorf RA, Velden J, Paust HJ, Panzer U, Ehmke H, Wenzel UO.
  Hypertension. 2014
  
  
• AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.
  Fraune C, Lange S, Krebs C, Hölzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garrelds IM, Danser AH, Frenay AR, van Goor H, Jankowski V, Stahl R, Nguyen G, Wenzel UO.
  Am J Physiol Renal Physiol. 2012
  
  
• Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
  Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Nickenig G, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S.
  Nat Med. 2010
  
  
• Rapid development of severe endorgan damage in C57black mice by combining DOCA salt and angiotensin II.
  Kirchhoff F, Krebs C, Abdulhag UN, Meyer-Schwesinger C, Maas R, Helmchen U, Hilgers K, Wolf G, Stahl RAK, Wenzel U.
  Kidney Int. 2008

• Studium der Medizin an der Universität Heidelberg
• Promotion (Dr. med.) am Institut für Pathologie an der Universität Heidelberg
• Postdoc am Institut für Physiologie I, Universität Heidelberg
• Habilitation und Venia Legendi für Physiologie, Universität Heidelberg
• Gast-Wissenschaftler am Max-Planck-Institut für medizinische Forschung Heidelberg, Abteilung für Zellphysiologie
• Gruppenleiter einer Nachwuchsforschungsgruppe in der Physiologie an der Universität Heidelberg
• Gast-Wissenschaftler am Europäisches Laboratorium für Molekularbiologie, Heidelberg
• Professur für Physiologie am UKE
  Ko-Sprecher der Forschergruppe 604
• Wissenschaftlicher Leiter des Zentrum für Experimentelle Medizin am UKE
• Sprecher der Translational Research Group des Deutschen Zentrum für Herz-Kreislauf-Forschung

• Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice.

  Rosendahl A, Kabiri R, Bode M, Cai A, Klinge S, Ehmke H, Mittrücker HW, Wenzel UOBr J Pharmacol. 2018 Sep

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Salt, inflammation, IL-17 and hypertension.

  Wenzel UO, Bode M, Kurts C, Ehmke H.Br J Pharmacol. 2018 May

• A pathogenic role of complement in arterial hypertension and hypertensive end organ damage.

  Wenzel UO, Bode M, Köhl J, Ehmke HAm J Physiol Heart Circ Physiol. 2017 Mar

• The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

  Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

• Immune Mechanisms in Arterial Hypertension

  Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

• The mechanotransduction of blood pressure.
  Ehmke H
  Science. 2018
  
  
• Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
  Heinze C, Seniuk A, Sokolov MV, Huebner AK, Klementowicz AE, Szijártó IA, Schleifenbaum J, Vitzthum H, Gollasch M, Ehmke H, Schroeder BC, Hübner CA.
  J Clin Invest. 2014
  
  
• Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice.
  Vitzthum H, Seniuk A, Schulte LH, Müller ML, Hetz H, Ehmke H.
  J Physiol. 2014
  
  
• Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate and angiotensin II-induced hypertension.
  Krebs CF, Lange S, Niemann G, Rosendahl A, Lehners A, Meyer-Schwesinger C, Stahl RA, Benndorf RA, Velden J, Paust HJ, Panzer U, Ehmke H, Wenzel UO.
  Hypertension. 2014
  
  
• Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis.
  Gröger N, Vitzthum H, Fröhlich H, Krüger M, Ehmke H, Braun T, Boettger T (2012).
  Hum Mol Genet. 2012
  
  
• Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
  Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Nickenig G, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S.
  Nat Med. 2010
  
  
• Control of heart rate by cAMP sensitivity of HCN channels.
  Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.
  Proc Natl Acad Sci U S A. 2009
  
  
• Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.
  Zimmermann WH, Melnychenko I, Wasmeier G, Didié M, Naito H, Nixdorff U, Hess A, Budinsky L, Brune K, Michaelis B, Dhein S, Schwoerer A, Ehmke H, Eschenhagen T.
  Nat Med. 2006

• Studium der Medizin und Physik an der Universität Göttingen
• Promotion (Dr. med.) im Institut für Immunologie an der Universität Göttingen
• Assistenzarzt und wissenschaftlicher Mitarbeiter in der Inneren Medizin an der Medizinischen Hochschule Hannover (MHH)
• Postdoc-Mitarbeiter am The Walter and Eliza Hall Institute for Medical Research (WEHI), Melbourne, Australia
• Habilitation in experimenteller Nephrologie
• Facharzt für Innere Medizin
• Arbeitsgruppenleiter in der Klinik für Nephrologie und Klinischer Immunologie, RWTH Aachen
• Heisenberg Stipendium der DFG
• C3 Professur für Molekulare Immunologie an der Universität Bonn
• Direktor des Instituts für Experimentelle Immunologie, Universität Bonn
• Co-Sprecher des SFB 704
• Co-Sprecher des SFB TR57 “Organ-Fibrosis” am Standort Bonn
• Gewähltes Mitglied der Deutsche Akademie der Naturforscher Leopoldina
• Gewähltes Mitglied im Fachkollegium Medizin der DFG
• Sprecher der Internationalen Graduiertenschule GRK 2168 Bo&MeRanG
  (Bonn & Melbourne Research and Graduate training Group)
• Vorstandsmitglied des DFG Excellence Cluster “ImmunoSensation²”, Bonn

• Sir Hans Krebs Preis für medizinischen Grundlagenwissenschaft (1999)
• Hans-U.-Zollinger-Preis der Deutschen Gesellschaft für Nephrologie (2010)
• Gottfried-Wilhelm-Leibniz-Preis der DFG (2012)

• Protecting the kidney against autoimmunity and inflammation.

  Christian Kurts, Catherine Meyer-SchwesingerNat Rev Nephrol. 2018 Dec

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Salt, inflammation, IL-17 and hypertension.

  Wenzel UO, Bode M, Kurts C, Ehmke H.Br J Pharmacol. 2018 May

• Pro-longed IKKβ inhibition improves ongoing CTL antitumor responses by incapacitating regulatory T cells.

  Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges JF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine AK, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.Cell Rep. 2017 Oct

• Fully automated evaluation of total glomerular num-ber and capillary tuft size in murine nephritic kidneys using lightsheet microscopy.

  Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Matthias GunzerJ Am Soc Nephrol. 2017 Feb

• Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Ag-gravates the Progression of crescentic glomerulonephritis.

  Gotot J, Piotrowski E, Otte MS, Tittel AP, Guo L, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss FJ Am Soc Nephrol. 2016 Jul

• CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

• A NLRP3-specific inflammasome inhibitor potently attenuates crystal-induced kidney fibrosis in vivo.

  Ludwig-Portugall I,*, Bartok E,* Dhana E, Evers BDG, Primiano MJ, Hall PJ, Franklin BS, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.Kidney Int 2016

• The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

  Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

• CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

  Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts CJ Am Soc Nephrol. 2016 Nov

• Immune Mechanisms in Arterial Hypertension

  Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

• Assessing core competences of medical students with a test for flight school applicants
  Harendza S, Soll H, Prediger S, Kadmon M, Berberat PO, Oubaid V
  BMC Med Educ. 2019
  
  
• Perceived strain of undergraduate medical students during a simulated first day of residency.
  Fürstenberg S, Prediger S, Kadmon M, Berberat PO, Harendza S
  BMC Med Educ. 2018
  
  
• Verbal and non-verbal communication skills including empathy during history taking of undergraduate medical students.
  Vogel D, Meyer M, Harendza S
  BMC Med Educ. 2018
  
  
• Implementation of a Clinical Reasoning Course in the Internal Medicine trimester of the final year of undergraduate medical training and its effect on students’ case presentation and differential diagnostic skills.
  Harendza S, Krenz I, Klinge A, Wendt U, Janneck M
  GMS J Med Educ. 2017
  
  
• Is perfect good? – Dimensions of perfectionism in newly admitted medical students.
  Seeliger H, Harendza S
  BMC Med Educ. 2017
  
  
• Competencies for first year residents – physicians’ views form medical schools with different undergraduate curricula.
  Fürstenberg S, Schick K, Deppermann J, Prediger S, Berberat PO, Kadmon M, Harendza S (2017).
  BMC Med Educ. 2017
  
  
• Influence of motivation, self-efficacy and situational factors on the teaching quality of clinical educators.
  Dybowski C, Sehner S, Harendza S (2017).
  BMC Med Educ. 2017
  
  
• Analysis of educational research at a medical faculty in Germany and suggestions for strategic development – a case study.
  Prediger S, Harendza S (2016).
  GMS J Med Educ. 2016
  
  
• Psychometric properties of the newly developed Physician Teaching Self-Efficacy Questionnaire (PTSQ).
  Dybowski C, Kriston L, Harendza S (2016).
  BMC Med Educ. 2016
  
  
• Translating medical documents into plain language enhances communication skills in medical students – A pilot study.
  Bittner A, Jonietz A, Bittner J, Beickert L, Harendza S (2015)
  Patient Educ Couns. 2015

• Studium der Humanmedizin an der Universität Frankfurt/Main
• Promotion (Dr. med.) an der Universität Frankfurt/Main
• Ärztin im Praktikum in der Nephrologie am Universitätsklinik Frankfurt/Main
• Postdoktorandenstipendium der DFG im Department of Nephrology, VAMC, University of California, San Francisco, USA
• Wissenschaftliche Mitarbeiterin in der III. Medizinische Klinik, UKE
• Master of Medical Education an der Universität Bern, Schweiz
• Fachärztin für Innere Medizin sowie für Nephrologie
• Habilitation in der Inneren Medizin, Universität Hamburg
• Oberärztin in der III. Medizinische Klinik, UKE
• Prodekanin für Lehre an der Medizinische Fakultät, Universität Hamburg (2006-2007)
• Universitätsprofessur (W3) für Innere Medizin/Ausbildungsforschung, III. Medizinische Klinik, UKE

• Assessing core competences of medical students with a test for flight school applicants 
  Harendza S, Soll H, Prediger S, Kadmon M, Berberat PO, Oubaid V
  BMC Med Educ 2019

• Perceived strain of undergraduate medical students during a simulated first day of residency.
  Fürstenberg S, Prediger S, Kadmon M, Berberat PO, Harendza S
  BMC Med Educ 2018

• Verbal and non-verbal communication skills including empathy during history taking of undergraduate medical students.
  Vogel D, Meyer M, Harendza S
  BMC Med Educ 2018

• Implementation of a Clinical Reasoning Course in the Internal Medicine trimester of the final year of undergraduate medical training and its effect on students’ case presentation and differential diagnostic skills.
  Harendza S, Krenz I, Klinge A, Wendt U, Janneck M
  GMS J Med Educ 2017

• Is perfect good? – Dimensions of perfectionism in newly admitted medical students.
  Seeliger H, Harendza S
  BMC Med Educ 2017

• Competencies for first year residents – physicians’ views form medical schools with different undergraduate curricula.
  Fürstenberg S, Schick K, Deppermann J, Prediger S, Berberat PO, Kadmon M, Harendza S
  BMC Med Educ 2017

• Influence of motivation, self-efficacy and situational factors on the teaching quality of clinical educators.
  Dybowski C, Sehner S, Harendza S
  BMC Med Educ 2017

• Analysis of educational research at a medical faculty in Germany and suggestions for strategic development – a case study.
  Prediger S, Harendza S
  GMS J Med Educ 2016

• Psychometric properties of the newly developed Physician Teaching Self-Efficacy Questionnaire (PTSQ).
  Dybowski C, Kriston L, Harendza S
  BMC Med Educ 2016

• Translating medical documents into plain language enhances communication skills in medical students – A pilot study.
  Bittner A, Jonietz A, Bittner J, Beickert L, Harendza S
  Patient Educ Couns 2015

• Bachelor-Abschluss in Biotechnologie, University of Milano-Bicocca (IT)
• Master-Abschluss in Medizinischer Biotechnologie, University of Milano-Bicocca (IT)
• Bachelor-Arbeit in Ospedale San Raffaele (IT)
• Master-Arbeit im Beth Israel Deaconess Medical Center, Harvard Medical
School (USA)
• Promotion (Ph.D.) in Molekularer Medizin, Università Vita-Salute San Raffaele (IT)
• Forschungsaufenthalt als Ph.D. Student an der Yale School of Medicine (USA)
• Postdoc-Stipendiat an der Yale School of Medicine, Department of Immunobiology (USA)
• Assistant Professor (25%) für Molekulare Medizin am Karolinska Institute, Stockholm (SE)
• W3 Professur für Gastrointestinale Karzinogenese am Universitätsklinikum Hamburg-Eppendorf

• Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

  Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson J, Antonson P, Roncarolo M, Villablanca E, Gagliani N, Huber SNat Commun. 2018 Dec

• IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.

  Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S.J Immunol. 2017 Feb

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

  Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

• TH17 cell plasticity: The role of dendritic cells and molecular mechanisms.
  Agalioti T, Villablanca EJ, Huber S, Gagliani N.
  J Autoimmun. 2018
  
  
• Intestinal IFN-γ-producing Tr1-cells co-express CCR5 and PD-1, and down-regulate IL-10 in the inflamed gut of IBD patients.
  Alfen JS*, Larghi P*, Facciotti F*, Gagliani N*, Bosotti R, Paroni M, Maglie S, Gruarin P, Vasco CM, Ranzani V, Frusteri C, Iseppon A, Moro M, Crosti MC, Gatti S, Pagani M, Caprioli F, Abrignani S, Flavell RA, Geginat J.
  J Allergy Clin Immunol. 2018
  
  
• Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.
  Bosurgi L, Cao Y G, Cabeza-Cabrerizo M, Tucci A, Hughes L D, Kong Y, Weinstein J S, Licona-Limon P, Schmid E T, Pelorosso F, Gagliani N, Craft J E, Flavell R A, Ghosh S, Rothlin C V.
  Science. 2017
  
  
• A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.
  Pelczar, P., M. Witkowski, L. G. Perez, J. Kempski, A. G. Hammel, L. Brockmann, D. Kleinschmidt, S. Wende, C. Haueis, T. Bedke, M. Witkowski, S. Krasemann, S. Steurer, C. J. Booth, P. Busch, A. Konig, U. Rauch, D. Benten, J. R. Izbicki, T. Rosch, A. W. Lohse, T. Strowig, N. Gagliani*, R. A. Flavell*, and S. Huber*. *contributed equally
  Science. 2016
  
  
• Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
  Gagliani, N., M. C. Amezcua Vesely, A. Iseppon, L. Brockmann, H. Xu, N. W. Palm, M. R. de Zoete, P. Licona-Limon, R. S. Paiva, T. Ching, C. Weaver, X. Zi, X. Pan, R. Fan, L. X. Garmire, M. J. Cotton, Y. Drier, B. Bernstein, J. Geginat, B. Stockinger, E. Esplugues, S. Huber*, and R. A. Flavell*. *contributed equally
  Nature. 2015
  
  
• The Fire Within: Microbes inflame tumor.
  Gagliani N*, Bo H*, Huber S*, Elinav E*, Flavell RA.
  Cell. 2014
  
  
• Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.
  Gagliani N*, Magnani CF*, Huber S*, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A, Trentini F, Di Serio C, Bacchetta R, Andreani M, Brockmann L, Gregori S, Flavell RA, Roncarolo MG. *contributed equally
  Nat Med. 2013
  
  
• Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
  Huber S*, Gagliani N*, Esplugues E*, O'Connor WJr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. *contributed equally
  Immunity. 2011

• Studium der Medizin an den Universitäten Freiburg, Wien und South Florida (USA)
• Promotion (Dr. med.) in Physiologie am Universitätsklinikum Freiburg, summa cum laude
• Assistenzarzt und Wissenschaftlicher Mitarbeiter in der Innere Medizin am Universitätsklinikum Freiburg
• Emmy Noether Program – Phase I/ Postdoc-Stipendiat, Immunologie & Pathologie, Washington University St. Louis, USA
• United states medical licensing examination (USMLE)
• Emmy Noether Programm – Phase II/ Arbeitsgruppenleiter an der Universität Freiburg
• Habilitation an der Universität Freiburg
• Facharzt für Innere Medizin und Facharzt für Nephrologie
• Oberarzt in der IV Medizinischen Klinik an der Universität Freiburg
• Heisenberg Stipendium an der Universität Freiburg
• W3-Heisenbergprofessur an der Universität Freiburg
• ERC Consolidator Grant
• Stellvertretender Leiter der IV. Medizinischen Klinik der Universität Freiburg
• Klinikdirektor der III. Medizinischen Klinik, UKE

• DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

  Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles V, Rahman R, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek M, Romano T, Moritz K, Boerries M, Busch H, Bonn S, Little M, Bechtel-Walz W, Huber TJ Am Soc Nephrol.. 2019 Jan.

• Development and validation of a renal risk score in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

• ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier.

  Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold HH, Dengjel J, Rogg M, Huber TB. Dev Cell. 2018 Dec

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

  Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. Cell Rep. 2018 May

• The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.
  Schell C, Rogg M, Suhm M, Helmstadter M, Sellung D, Yasuda-Yamahara M, Kretz O, Kuttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, and Huber TB.
  Proc Natl Acad Sci U S A. 2017
  
  
• mTORC2 critically regulates renal potassium handling.
  Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, and Huber TB.
  J Clin Invest. 2016
  
  
• Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.
  Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, and Pearce EL.
  Cell. 2016
  
  
• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
  Godel M, Grahammer F, and Huber TB.
  N Engl J Med. 2015
  
  
• Calciphylaxis.
  Zhou Q, Neubauer J, Kern JS, Grotz W, Walz G, and Huber TB.
  Lancet. 2014
  
  
• mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.
  Grahammer F, Haenisch N, Steinhardt F, Sandner L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, and Huber TB.
  Proc Natl Acad Sci U S A. 2014
  
  
• Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.
  Godel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S, Debreczeni-Mor A, Lindenmeyer MT, Rastaldi MP, Hartleben G, Wiech T, Fornoni A, Nelson RG, Kretzler M, Wanke R, Pavenstadt H, Kerjaschki D, Cohen CD, Hall MN, Ruegg MA, Inoki K, Walz G, and Huber TB.
  J Clin Invest. 2011
  
  
• Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
  Hartleben B, Godel M, Meyer-Schwesinger C, Liu S, Ulrich T, Kobler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstadt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, and Huber TB.
  J Clin Invest. 2010