Publikationen 2021
Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier.
Koehler S, Odenthal J, Ludwig V, Jess DU, Höhne M, Jüngst C, Grawe F, Helmstädter M, Janku JL, Bergmann C, Hoyer PF, Hagmann HHH, Walz G, Bloch W, Niessen C, Schermer B, Wodarz A, Denholm B, Benzing T, Iden S, Brinkkoetter PT.
Kidney Int. 2021 Dec
IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases
Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf Panzer
JASN 2021 Dec
IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases.
Schmidt T, Luebbe J, Kilian C, Riedel JH, Hiekmann S, Asada N, Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A, Flavell RA, Gagliani N, Pelzcar P, Huber S, Huber TB, Turner JE, Paust HJ, Krebs CF, Panzer U.
J Am Soc Nephrol. 2021 Dec
Renal Denervation Exacerbates LPS- and Antibody-induced Acute Kidney Injury, but Protects from Pyelonephritis in Mice.
Alexander M C Böhner, Alice M Jacob, Christoph Heuser, Natascha E Stumpf, Alexander Effland, Zeinab Abdullah, Catherine Meyer-Schwesiger, Sibylle von Vietinghoff, Christian Kurts
J Am Soc Nephrol. 2021 Oct
Neutralization of IL-6 inhibits formation of autoreactive TH17 cells but does not prevent loss of renal function in experimental autoimmune glomerulonephritis.
Brede KM, Schmid J, Steinmetz OM, Panzer U, Klinge S, Mittrücker HW.
Immuno Lett. 2021 Aug
Tissue-specific therapy in immune-mediated kidney diseases: new ARGuments for targeting the IL-23/IL-17 axis.
Krebs CF, Tuner JE, Riedel JH, Panzer U
J Clin Invest. 2021 Jun
Perspectives in membranous nephropathy
Tomas NM, Huber TB, Hoxha E.
Cell Tissue Res. 2021 Apr
A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood.
Likai Tan, Alina Suzann Fichtner, Elena Bruni, Ivan Odak, Inga Sandrock, Anja Bubke, Alina Borchers, Christian Schultze-Florey, Christian Koenecke, Reinhold Förster, Michael Jarek, Constantin von Kaisenberg, Ansgar Schulz, Xiaojing Chu, Bowen Zhang, Yang Li, Ulf Panzer, Christian F Krebs, Sarina Ravens, Immo Prinz
Sci Immunol. 2021 Apr
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.
Yan B*, Freiwald T*, Chauss D*, Wang L*, West E*, Mirabelli C, Zhang CJ, Nichols EM, Malik N, Gregory R, Bantscheff M, Ghidelli-Disse S, Kolev M, Frum T, Spence JR, Sexton JZ, Alysandratos KD, Kotton DN, Pittaluga S, Bibby J, Niyonzima N, Olson MR, Kordasti S, Portilla D, Wobus CE, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M.
Sci Immunol. 2021 Apr
ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage
Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C.
J Am Soc Nephrol. 2021 Mar
SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance
Rogg M, Maier JI, Dotzauer R, Artelt N, Kretz O, Helmstädter M, Abed A, Sammarco A, Sigle A, Sellung D, Dinse P, Reiche K, Yasuda-Yamahara M, Biniossek ML, Walz G, Werner M, Endlich N, Schilling O, Huber TB, Schell C.
J Am Soc Nephrol. 2021 Mar
Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.
Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiss C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lutgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF.
Sci Immunol. 2021 Feb
Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF
Sci Immunol. 2021 Feb
Rituximab Induces Complete Remission of Proteinuria in a Patient With Minimal Change Disease and No Detectable B Cells
Webendörfer M, Reinhard L, Stahl RAK, Wiech T, Mittrücker HW, Harendza S, Hoxha E.
Front Immunol. 2021 Feb
A New Chemiluminescence Immunoassay for Phospholipase A2 Receptor 1 Autoantibodies Allows Early Identification of Autoantibody Recurrence in Patients With Membranous Nephropathy.
Elion Hoxha, Rolf A K Stahl, Linda Reinhard, Alexander Kühnl, Wolfgang Schlumberger, Cornelia Dähnrich
Kidney Int. Rep. 2021 Jan