This figure illustrates the main topics of and interactions between the projects of section B of CRC 1192. Projects B1-3 and B5 will focus on membranous nephropathy (MN) and elucidate the pathogenic role of PLA2R and THSD7A autoantibodies on the structural and functional level. Projects B3 and B5 will address general mechanisms of podocyte injury mediated by the proteasome (B3) and purinergic receptors (B5). Moreover, B5 will test the role of nanobodies as a novel class of biologics in different forms of GN. Project B6 is aimed at better characterizing complementmediated C3 glomerulopathies and at defining the mutations involved. Project B8 is designed to better understand how immune cell-derived factors promote podocyte injury in FSGS, and Project B9 will investigate the interaction of parietal cells and the immune system in GN.