Zipfel – SFB1192

ApoE attenuates unresolvable inflammation by complex formation with activated C1q.

Yin C, Ackermann S, Ma Z, Mohanta SK, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Markus Hildner M, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Habenicht L, Binder CJ, Weber C*, Zipfel PF *, Skerka C*, Habenicht AJR*
Nat Med. 2019 Mar
*equal contribution

C3 Glomerulopathy-Understanding a Rare Complement-Driven Renal Disease.

Smith RJH, Appel G, Blom AM, Cook HT, D’Agati V, Fakhouri F, Véronique Fremeaux-Bacchi V, Józsi M, Kavanagh D, Lambris J, Noris M, Pickering MC, Remuzzi G, Santiago Rodriguez de Córdoba S, Sethi S, Van der Vlag J, Zipfel PF, Nester CM
Nat Rev Nephrol. 2019 Mar

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.

Zhao F, Afonso S, Lindner S, Hartmann A, Löschmann I, Nilsson B, Ekdahl KN, Weber LT, Habbig S, Schalk G, Kirschfink M, Zipfel PF, Skerka C.
Front Immunol. 2019 May

CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

Zipfel PF, Wiech T, Stea ED, Skerka C.
J Am Soc Nephrol. 2020 Feb

FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.

Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C
J Immunol. 2016 Jul

FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PF
J Immunol. 2018 Apr

ApoE attenuates unresolvable inflammation by complex formation with activated C1q.

C3 Glomerulopathy-Understanding a Rare Complement-Driven Renal Disease.

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.

CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.

FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

The Case | A 78-year-old woman with acute kidney injury and hemolytic anemia.

The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension.

III. Medizinische Klinik und Polyklinik Universitätsklinikum Hamburg-Eppendorf