Publications
Pathogenic T-Cell Responses in Immune-Mediated Glomerulonephritis
Linke A, Tiegs G, Neumann K.
Cells. 2022 May
Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy
Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Müller-Deile J, Schlüter H, Puelles VG, Bergmann C, Huber TB, Grahammer F.
J Clin Invest. 2022 May
The Amphiregulin/EGFR axis protects from lupus nephritis via downregulation of pathogenic CD4+ T helper cell responses.
Simon Melderis, Matthias T Warkotsch, Julien Dang, Julia Hagenstein, Laura-Isabell Ehnold, Georg R Herrnstadt, Christoph B Niehus, Frederic C Feindt, Dominik Kylies, Victor G Puelles, Carmen Berasain, Matias A Avila, Katrin Neumann, Gisa Tiegs, Tobias B Huber, Pierre-Louis Tharaux, Oliver M Steinmetz.
J Autoimmun 2022 May
Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8 + T Cells
Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz OM, Diehl L, Tiegs G, Neumann K.
Cells. 2022 Apr
Conventional NK Cells and Type 1 Innate Lymphoid Cells Do Not Influence Pathogenesis of Experimental Glomerulonephritis.
Constantin Rickassel, Ann-Christin Gnirck, Nikhat Shaikh, Virginia Adamiak, Alex Waterhölter, Yakup Tanriver, Katrin Neumann, Tobias B Huber, Georg Gasteiger, Ulf Panzer, Jan-Eric Turner
J Immunol. 2022 Apr
Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.
Bartsch P, Kilian C, Hellmig M, Paust HJ, Borchers A, Sivayoganathan V, Enk L, Zhao Y, Shaikh N, Büttner H, Wong MN, Puelles VG, Wiech T, Flavell R, Huber TB, Turner JE, Bonn S, Huber H, Gagliani N, Mittrücker HW, Rohde H, Panzer U, Krebs CF.
PLoS Pathog. 2022 Apr
Membranous nephropathy: new pathogenic mechanisms and their clinical implications.
Elion Hoxha, Linda Reinhard, Rolf A K Stahl
Nat Rev Nephrol. 2022 Apr
Molecular consequences of SARS-CoV-2 liver tropism
Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer MT, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB.
Nat Metab. 2022 Mar
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells.
Chauss D*, Freiwald T*, McGregor R*, Yan B*, Wang L*, Nova-Lamperti E, Kumar D, Zhang Z, Teague H, West EE, Vannella KM, Ramos-Benitez MJ, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz DM, Portilla D, Chertow DS, John S, Lavender P, Kemper C, Lombardi G, Mehta NN, Cooper N, Lionakis MS, Laurence A, Kazemian M, Afzali B.
Nat Immunol. 2022 Jan
Across scales: novel insights into kidney health and disease by structural biology.
Nicola M Tomas, Simon A Mortensen, Matthias Wilmanns, Tobias B Huber
Kidney Int. 2021 Apr
Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier.
Koehler S, Odenthal J, Ludwig V, Jess DU, Höhne M, Jüngst C, Grawe F, Helmstädter M, Janku JL, Bergmann C, Hoyer PF, Hagmann HHH, Walz G, Bloch W, Niessen C, Schermer B, Wodarz A, Denholm B, Benzing T, Iden S, Brinkkoetter PT.
Kidney Int. 2021 Dec
IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases
Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf Panzer
JASN 2021 Dec
IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases.
Schmidt T, Luebbe J, Kilian C, Riedel JH, Hiekmann S, Asada N, Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A, Flavell RA, Gagliani N, Pelzcar P, Huber S, Huber TB, Turner JE, Paust HJ, Krebs CF, Panzer U.
J Am Soc Nephrol. 2021 Dec
Renal Denervation Exacerbates LPS- and Antibody-induced Acute Kidney Injury, but Protects from Pyelonephritis in Mice.
Alexander M C Böhner, Alice M Jacob, Christoph Heuser, Natascha E Stumpf, Alexander Effland, Zeinab Abdullah, Catherine Meyer-Schwesiger, Sibylle von Vietinghoff, Christian Kurts
J Am Soc Nephrol. 2021 Oct
Neutralization of IL-6 inhibits formation of autoreactive TH17 cells but does not prevent loss of renal function in experimental autoimmune glomerulonephritis.
Brede KM, Schmid J, Steinmetz OM, Panzer U, Klinge S, Mittrücker HW.
Immuno Lett. 2021 Aug
Tissue-specific therapy in immune-mediated kidney diseases: new ARGuments for targeting the IL-23/IL-17 axis.
Krebs CF, Tuner JE, Riedel JH, Panzer U
J Clin Invest. 2021 Jun
Perspectives in membranous nephropathy
Tomas NM, Huber TB, Hoxha E.
Cell Tissue Res. 2021 Apr
A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood.
Likai Tan, Alina Suzann Fichtner, Elena Bruni, Ivan Odak, Inga Sandrock, Anja Bubke, Alina Borchers, Christian Schultze-Florey, Christian Koenecke, Reinhold Förster, Michael Jarek, Constantin von Kaisenberg, Ansgar Schulz, Xiaojing Chu, Bowen Zhang, Yang Li, Ulf Panzer, Christian F Krebs, Sarina Ravens, Immo Prinz
Sci Immunol. 2021 Apr
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.
Yan B*, Freiwald T*, Chauss D*, Wang L*, West E*, Mirabelli C, Zhang CJ, Nichols EM, Malik N, Gregory R, Bantscheff M, Ghidelli-Disse S, Kolev M, Frum T, Spence JR, Sexton JZ, Alysandratos KD, Kotton DN, Pittaluga S, Bibby J, Niyonzima N, Olson MR, Kordasti S, Portilla D, Wobus CE, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M.
Sci Immunol. 2021 Apr
Deep learning-based molecular morphometrics in kidney biopsies.
Zimmermann M*, Klaus M*, Wong MN, Thebille AK, Gernhold L, Kuppe C, Halder M, Kranz J, Wanner N, Braun F, Wulf S, Wiech T, Panzer U, Krebs CF, Hoxha E, Kramann R, Huber TB*, Bonn S*, Puelles VG*.
JCI Insight. 2021 Apr