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SFB 1192

Project A6

Innate and innate-like lymphocytes in immune-mediated glomerular diseases

Lymphocytes of the innate and adaptive immune system are central regulators of immune responses in homeostasis and immune-mediated diseases. Recent studies from our group and others have shown that specialized subsets of innate lymphocytes and “innate-like” T cells reside in the kidney and regulate local immune responses. However, the contribution of these innate and innate-like lymphocyte populations to kidney injury and repair in immune-mediated glomerular diseases remains incompletely understood. Preliminary studies by our group suggest that specific interactions between innate-like T cell populations with other immune cells and kidney epithelial cells are crucial for immune regulation in immune-mediated glomerular disease.
By using sc(nuc)RNAseq and spatial tissue analyses (spatial transcriptomics and imaging) we will decipher transcriptional programs and spatial distribution of innate-like T cells and neighboring kidney epithelial cells in different entities of immune-mediated glomerular diseases (ANCA glomerulonephritis, Lupus nephritis, IgA nephropathy). Next, novel complex immune cell – 3D kidney organoid systems will be employed to model kidney diseases in vitro with human cells and investigate the regulation of kidney epithelial cells by innate-like T cells. Finally, selected candidate pathways will be functionally validated in mouse models of glomerulonephritis. In summary, our studies will elucidate the role of innate-like T cells in immune-mediated glomerular diseases and identify targets to develop tailored treatment approaches in patients with glomerulonephritis

Publications

  • Conventional NK Cells and Type 1 Innate Lymphoid Cells Do Not Influence Pathogenesis of Experimental Glomerulonephritis.

    Constantin Rickassel, Ann-Christin Gnirck, Nikhat Shaikh, Virginia Adamiak, Alex Waterhölter, Yakup Tanriver, Katrin Neumann, Tobias B Huber, Georg Gasteiger, Ulf Panzer, Jan-Eric Turner J Immunol. 2022 Apr

  • Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.

    Yu Zhao, Christoph Kilian, Jan-Eric Turner, Lidia Bosurgi, Kevin Roedl, Patricia Bartsch, Ann-Christin Gnirck, Filippo Cortesi, Christoph Schultheiß, Malte Hellmig, Leon U B Enk, Fabian Hausmann, Alina Borchers , Milagros N Wong, Hans-Joachim Paust , Francesco Siracusa, Nicola Scheibel, Marissa Herrmann, Elisa Rosati, Petra Bacher , Dominik Kylies, Dominik Jarczak, Marc Lütgehetmann, Susanne Pfefferle, Stefan Steurer, Julian Schulze Zur-Wiesch, Victor G Puelles, Jan-Peter Sperhake, Marylyn M Addo, Ansgar W Lohse, Mascha Binder, Samuel Huber, Tobias B Huber, Stefan Kluge, Stefan Bonn, Ulf Panzer , Nicola Gagliani, Christian F Krebs.Sci Immunol. 2021 Feb

  • Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

    Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.Kidney Int. 2020 Sep

  • Innate Lymphoid Cells in Renal Inflammation.

    Becker M, Gnirck AC, Turner JEFront Immunol. 2020 Jan

  • Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

    Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

  • T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus. 

    Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JEEur J Immunol. 2018 Aug

  • Innate lymphoid cells in autoimmunity and chronic inflammatory diseases. 

    Xiong T, Turner JESemin Immunopathol. 2018 Jul

  • Innate Lymphoid Cells – Key players in tissue-specific immunity. 

    Turner JE, Gasteiger GSemin Immunopathol. 2018 Jul

  • Tissue-Resident Lymphocytes in the Kidney.

    Jan-Eric Turner, Martina Becker, Hans-Willi Mittrücker, Ulf Panzer J Am Soc Nephrol. 2018 Feb

  • Natural killers: the bad guys in fibrosis? 

    Turner JEKidney Int. 2017 Jul

  • IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

    Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

Project-Team

Project Leader
Prof. Dr. med. Jan-Eric Turner
Prof. Dr. Madeleine Bunders