SFB 1192

Project A6

Function of IL-22 and IL-9 in glomerulonephritis

The cytokines IL-22 and IL-9 are important regulators of tissue responses in inflammation and under homeostatic conditions. They are produced by T cell subsets and cells of the innate immune system. While IL-22 signaling exclusively targets tissue resident cells, IL-9 mainly exerts its effect by modulating the function of immune cells in an auto- and paracrine manner. Both cytokines have been implicated in autoimmune inflammation, as well as in tissue remodeling and repair processes. The role of these mediators in kidney disease is largely unknown. This project investigates IL-22- and IL-9-producing immune cells and their function in the immunopathogenesis of glomerulonephritis (GN).

By using fluorescent reporter mice for IL-22 and IL-9, as well as cytokine-deficient mice and blocking antibodies, we will address the expression pattern and function of the two cytokines in mouse models of GN. In addition, we will characterize IL-22+ and IL-9+ cells in the blood and kidney of patients with GN and analyze changes in these cell populations under immunosuppressive therapy. The long-term aim of this project is to increase the understanding of IL-22 and IL-9 biology in renal inflammation and to potentially identify novel therapeutic targets for treatment of patients with immune-mediated glomerular disease.

Publications

  • Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

    Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

  • T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus. 

    Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JEEur J Immunol. 2018 Aug

  • Innate lymphoid cells in autoimmunity and chronic inflammatory diseases. 

    Xiong T, Turner JESemin Immunopathol. 2018 Jul

  • Innate Lymphoid Cells – Key players in tissue-specific immunity. 

    Turner JE, Gasteiger GSemin Immunopathol. 2018 Jul

  • Tissue-Resident Lymphocytes in the Kidney. 

    Turner JE, Becker M, Mittrücker HW, Panzer UJ Am Soc Nephrol. 2018 Feb

  • Natural killers: the bad guys in fibrosis? 

    Turner JEKidney Int. 2017 Jul

  • IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

    Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

III. Medizinische Klinik und Poliklinik
Universitätsklinikum Hamburg-Eppendorf

Martinistrasse 52
20246 Hamburg, Germany
Tel:   +49-40-7410-51557
Fax:  +49-40-7410-59036
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