SFB 1192

Projekt C1

Hamburg Glomerulonephritis Registry

The Hamburg Glomerulonephritis Registry is an integral part of the CRC1192. Its purpose is to study a large cohort of patients with immune-mediated glomerular diseases including membranous nephropathy (MN), membranoproliferative glomerulonephritis (MPGN/C3 glomerulopathy), ANCA-associated glomerulonephritis, lupus nephritis, anti GBM nephritis, fibrillary glomerulonephritis, minimal change disease (MCD), primary focal and segmental glomerulosclerosis (FSGS), etc. Renal biopsies, blood samples as well as genetic and clinical data will be collected from all patients included in the registry. Starting point for data collection will be the renal biopsy, followed by regular clinical and laboratory assessments of the participating patients. Participants will be followed longitudinally to enable the PIs of the CRC to investigate the pathomechanisms of disease, characterise prognostic factors, response to therapy, and disease progression, with the ultimate objective to cure these glomerular diseases.

For further information about the Hamburg Glomerulonephritis Registry can be found here.

Publications

Publications with involvement of project C1:

Diagnostic role of renal biopsy in PLA2R1-antibody positive patients with nephrotic syndrome. 
Wiech T, Stahl RAK, Hoxha E (2019). 
Mod Pathol. In Print.

Genetics of membranous nephropathy. 
Gupta S, Köttgen A, Hoxha E, Brenchley P, Bockenhauer D, Stanescu HC, Kleta R (2018). 
Nephrol Dial Transplant 33:1493-1502

Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy. 
von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E*, Stahl RAK* (2018). 
Front Immunol 9:3035. doi: 10.3389/fimmu.2018.03035. . *: equal contribution.

Bevacizumab-associated glomerular microangiopathy. 
Person F, Rinschen MM, Brix SR, Wulf S, Noriega MLM, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz OM, Reinhard L, Hoxha E, Zipfel PF, Bräsen JH, Wiech T (2018). 
Mod Pathol doi: 10.1038/s41379-018-0186-4. [Epub ahead of print]

Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis. 
Brix SR, Noriega M, Herden EM, Goldmann B, Langbehn U, Busch M, Jabs WJ, Steinmetz OM, Panzer U, Huber TB, Stahl RAK, Wiech T (2018).
Histopathology 72:1093-1101.

IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 
Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer U (2018). 
J Am Soc Nephrol 29:1210-1222.

Development and validation of a renal risk score in ANCA-associated glomerulonephritis. 
Brix SR, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs WJ, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber TB, Waldherr R, Hopfer H, Stahl RAK, Wiech T (2018). 
Kidney Int 94:1177-1188.

The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy. 
Seifert L*, Hoxha E*, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NM (2018). 
J Am Soc Nephrol 29:1536-1548. *: equal contribution.

Immunohistochemical and serological characterization of membranous nephropathy in children and adolescents. 
Dettmar AK, Wiech T, Kemper MJ, Soave A, Rink M, Oh J, Stahl RAK, Hoxha E (2018). 
Pediatr Nephrol 33:463-472

A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy. 
Tomas NM, Meyer-Schwesinger C, von Spiegel H, Kotb AM, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl RAK (2017). 
J Am Soc Nephrol 28:3262-3277

THSD7A expression in human cancer.
Stahl PR, Hoxha E, Wiech T, Schröder C, Simon R, Stahl RA (2017). 
Genes Chromosomes Cancer 56:314-327

An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy. 
Hoxha E, Beck LH Jr, Wiech T, Tomas NM, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl PR, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant DJ, Stahl RA (2017).
J Am Soc Nephrol 28:520-531

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 
Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RAK, Huber S, Turner JE, Panzer U (2016). 
Immunity 45:1078-1092.

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 
Tomas NM*, Hoxha E*, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C§, Stahl RA§ (2016). 
J Clin Invest 126:2519-2532. *§: equal contribution.

A Mechanism for Cancer-Associated Membranous Nephropathy. 
Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RA (2016). 
N Engl J Med 374:1995-1996

III. Medizinische Klinik und Poliklinik
Universitätsklinikum Hamburg-Eppendorf

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