This figure illustrates the main topics of and the connections between projects of area A. The potential functions of leukocyte subsets in the kidney are shown in a schematic representation, highlighting the key focus of each project. Immune cell trafficking, residency and localization will be addressed by projects A1, A3, A4, A6 and A8.
The immune regulatory function of T cells, their plasticity and target antigens, will be the focus of projects A2, A3, A4 and A5. Project A4, A3, A6 and A1 will investigate the role of tissue-resident T cell / innate lymphocyte responses. The function of myeloid cell subsets, as well as their interaction with T cells, in immune-mediated glomerular diseases will be analyzed by projects A1, A6 and A8, respectively.
Projects A1 – A8 will collaborate on the investigation of effector functions of T cell subsets, innate and innatelike
lymphocytes (e.g. MAIT cells) and myeloid cell subsets to unravel the mechanisms by which these immune cells affect renal parenchymal cells to mediate glomerular injury (Illustration: www.hegasy.de).