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SFB 1192

Emmy Noether Research Group Turner

Innate Lymphoid Cells in Renal Inflammation

In the last few years a new population of lymphocytes that belongs to the innate arm of the immune system has been identified and studied extensively. Because of their antigen-independent activation and lymphoid morphology these cells have been termed “Innate Lymphoid Cells“ (ILCs).

In recent studies by us and others, it has been shown that IL-5- and IL-13-producing ILCs are crucial for the regulation of eosinophil abundance and the differentiation of alternatively activated macrophages in various tissues. Thereby, and by producing mediators that directly enhance epithelial regeneration, these ILCs can contribute to tissue remodeling and repair processes after acute tissue injury.

First evidence indicates that ILCs are present in the healthy human and murine kidney and that the sustained expansion of kidney-residing ILCs by systemic cytokine treatment can enhance tissue repair in mouse models of kidney injury. The role of ILC subtypes in the kidney as a source of T helper-cell-associated cytokines and their function in renal inflammation await further study.

The long-term aim of the Emmy Noether Research Group, funded by the DFG since March 2015, will be to evaluate kidney-residing ILCs as a potential therapeutic target for modulation of the immune response in inflammatory kidney diseases.

Publications

Conventional NK Cells and Type 1 Innate Lymphoid Cells Do Not Influence Pathogenesis of Experimental Glomerulonephritis.

Constantin Rickassel, Ann-Christin Gnirck, Nikhat Shaikh, Virginia Adamiak, Alex Waterhölter, Yakup Tanriver, Katrin Neumann, Tobias B Huber, Georg Gasteiger, Ulf Panzer, Jan-Eric Turner
J Immunol. 2022 Apr

IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases

Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf Panzer
JASN 2021 Dec

Tissue-specific therapy in immune-mediated kidney diseases: new ARGuments for targeting the IL-23/IL-17 axis.

Krebs CF, Tuner JE, Riedel JH, Panzer U
J Clin Invest. 2021 Jun

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF
Sci Immunol. 2021 Feb

Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.
Kidney Int. 2020 Sep

Innate Lymphoid Cells in Renal Inflammation.

Becker M, Gnirck AC, Turner JE
Front Immunol. 2020 Jan

Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JE
Am J Physiol Renal Physiol. 2019 Apr

T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus. 

Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JE
Eur J Immunol. 2018 Aug

Innate lymphoid cells in autoimmunity and chronic inflammatory diseases. 

Xiong T, Turner JE
Semin Immunopathol. 2018 Jul

Innate Lymphoid Cells – Key players in tissue-specific immunity. 

Turner JE, Gasteiger G
Semin Immunopathol. 2018 Jul

Tissue-Resident Lymphocytes in the Kidney.

Jan-Eric Turner, Martina Becker, Hans-Willi Mittrücker, Ulf Panzer
J Am Soc Nephrol. 2018 Feb

Natural killers: the bad guys in fibrosis? 

Turner JE
Kidney Int. 2017 Jul

IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JE
J Am Soc Nephrol. 2017 Jul

Immune Mechanisms in Arterial Hypertension

Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H
J Am Soc Nephrol. 2016 Mar

Project-Team

Projectleader:
PD. Dr. Jan-Eric Turner

Co-Worker:
Martina Becker