SFB 1192

Project Leader

Prof. Dr. med. Ulf Panzer

Project Leader A1

Leader of the Section Translational Immunology
Co-Speaker of the SFB 1192
Medical Specialist in Internal Medicine and Nephrology
III. Department of Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 51557
Fax  +49 (0) 40 7410 - 59036
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine at the University Hamburg
  • M.D. thesis in the Medizinische Kernklinik, UKE
  • Assistant Physician at the III. Medizinische Klinik, UKE
  • Study of Molecular Biology at the Centre of Molecular Neurobiology Hamburg
  • DFG Fellowship at the Institute for Research in Biomedicine, Bellinzona Switzerland
  • Clinical Specialization in Internal Medicine and Nephrology
  • Habilitation in Internal Medicine, University Hamburg
  • Leader of the Clinical Research Unit 228 “Immunopathogenesis of GN”
  • W3 Professor at the III. Medizinische Klinik, UKE
  • Deputy Coordinator of the SFB 1192
  • Leader of the Section Translational Immunology, UKE
Awards
  • Franz-Volhard-Preis der Deutschen Gesellschaft für Nephrologie
Publications during the first funding period of the SFB 1192

  • Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T-cell responses.

    Breda PC, Wiech T, Meyer-Schwesinger C, Grahammer F, Huber TB, Panzer U, Tiegs G, Neumann K.Am J Physiol Renal Physiol. 2019 Apr

  • Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

    Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

  • The role of regulatory T cells in Experimental Autoimmune Glomerulonephritis.

    Klinge S, Yan K, Reimers D, Brede KM, Schmid J, Paust HJ, Krebs CF, Panzer U, Hopfer H, Mittrücker H-W. Am J Physiol Renal Physiol 2019 Mar

  • The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.

    Neumann K, Ostmann A, Breda PC, Ochel A, Tacke F, Paust HJ, Panzer U, Tiegs G Sci Rep. 2019 Feb

  • Development and validation of a renal risk score in ANCA-associated glomerulonephritis

    Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

  • T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus. 

    Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JEEur J Immunol. 2018 Aug

  • Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

    Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

  • IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

    Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

  • Tissue-Resident Lymphocytes in the Kidney. 

    Turner JE, Becker M, Mittrücker HW, Panzer UJ Am Soc Nephrol. 2018 Feb

  • Host DNases prevent vascular occlusion by neutrophil extracellular traps.

    Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TAScience. 2017 Dec

  • T helper type 17 cells in immune-mediated glomerular disease

    Krebs C, Schmidt T, Riedel J, Panzer U Nat Rev Nephrol. 2017 Oct

  • IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

    Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

  • An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

    Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

  • T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

    Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Ag-gravates the Progression of crescentic glomerulonephritis.

    Gotot J, Piotrowski E, Otte MS, Tittel AP, Guo L, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss FJ Am Soc Nephrol. 2016 Jul

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

  • Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

    Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

  • A Mechanism for Cancer-Associated Membranous Nephropathy. 

    Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

  • CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

    Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts CJ Am Soc Nephrol. 2016 Nov

  • IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

    Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

  • RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

    Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

    Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

Further selected Publications
  • CXCL5 Drives Neutrophil Recruitment in TH17-Mediated GN
    Disteldorf E, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RAK, Kurts C, Kaufmann SHE, Panzer U.
    J Am Soc Nephrol. 2015
  • The immune system and kidney disease: basic concepts and clinical implications.
    Kurts C*, Panzer U*, Anders HJ, Rees AJ*contributed equally
    Nat Rev Immunol. 2013
  • Micro-RNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN.
    Krebs CF, Kapffer S, Paust HJ, Schmidt T, Bennstein SB, Peters A, Stege G, Brix SR, Meyer-Schwesinger C, Müller RU, Turner JE, Steinmetz OM, Wolf G, Stahl RA, Panzer U
    J Am Soc Nephrol. 2013
  • Immature renal DC recruit regulatory CXCR6+ iNKT cells to attenuate crescentic GN.
    Riedel JH, Paust HJ, Turner JE, Tittel AP, Krebs C, Disteldorf E, Tiegs G, Velden J, Mittrücker HW, Garbi N, Stahl RA, Steinmetz OM, Kurts C, Panzer U
    J Am Soc Nephrol. 2012
  • The IL-23 / Th17 axis contributes to renal tissue damage in experimental glomerulonephritis.
    Paust HJ, Turner JE, Steinmetz OM, Peters A, Heymann F, Hölscher C, Wolf G, Kurts C, Mittrücker HW, Stahl RA, Panzer U
    J Am Soc Nephrol. 2009

Prof. Dr. med. Rolf A.K. Stahl

Project Leader B1 and C1

Speaker of SFB 1192
Medical Specialist for Internal Medicine and Nephrology
III. Department of Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 59017
Fax  +49 (0) 40 7410 - 49017
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Medical School, University of Tübingen
  • M.D. Thesis University of Tübingen
  • Internship, Hospital Siloah, Pforzheim
  • Residency, Department of Pathology, University of Tübingen
  • Buswell Fellow and Research Assistant Professor of Medicine, Department of Medicine, SUNY Buffalo, NY, USA
  • Residency, Internal Medicine, Department of Medicine, University of Freiburg
  • Habilitation in Internal Medicine, University of Freiburg
  • Visiting Scholar, Division of Nephrology, Department of Medicine, University of Washington, Seattle, USA
  • Associate Professor of Medicine, University Hospital, Frankfurt am Main
  • Professor of Medicine, Head, III. Medizinische Klinik, University of Hamburg
  • Senior Professor of Medicine, Medical Faculty, University of Hamburg
Awards
  • Franz-Volhard-Medaille of the German society of Nephrologie (2017)
Publications during the first funding period of the SFB 1192

  • Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy.

    Mahmud M, Pinnschmidt HO, Reinhard L, Harendza S, Wiech T, Stahl RAK, Hoxha E PLoS One. 2019 Sep

  • Diagnostic role of renal biopsy in PLA2R1-antibody-positive patients with nephrotic syndrome.

    Wiech T, Stahl RAK, Hoxha E Mod Pathol. 2019 Sep

  • Development and validation of a renal risk score in ANCA-associated glomerulonephritis

    Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

  • Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

    von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAKFront Immunol. 2018 Dec

  • Characterization of Autoantibodies in Primary Membranous Nephropathy and their clinical Significance.

    Stahl RAK, Reinhard L, Hoxha E.Expert Rev Clin Immunol. 2018 Nov

  • The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

    Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

  • IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

    Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

  • Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

    Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

  • The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

    Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

  • IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

    Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

  • Immunohistochemical and serological characterization of membranous nephropathy in children and adolescents

    Dettmar A, Wiech T, Kemper M, Soave A, Rink M, Oh J, Stahl R, Hoxha E Pediatr Nephrol. 2018 Mar

  • Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

    Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

  • A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

    Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

  • Translational Aspects of Primary Membranous Nephropathy.

    Hoxha E, Stahl RAK.Semin Nephrol. 2017 Sep

  • Membranous nephropathy-one morphologic pattern with different diseases

    Hoxha E, von Haxthausen F, Wiech T, Stahl RPflugers Arch. 2017 Aug

  • IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

    Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

  • THSD7A expression in human cancer

    Stahl P, Hoxha E, Wiech T, Schröder C, Simon R, Stahl R Genes Chromosomes Cancer. 2017 Apr

  • RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

    Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

  • An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

    Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

  • T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

    Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

    Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

  • The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

    Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

  • Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

    Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

  • A Mechanism for Cancer-Associated Membranous Nephropathy. 

    Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

  • IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

    Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

  • RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

    Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

    Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

Further selected Publications
  • CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.
    Brix SR, Stege G, Disteldorf E, Hoxha E, Krebs C, Krohn S, Otto B, Klätschke K, Herden E, Heymann F, Lira SA, Tacke F, Wolf G, Busch M, Jabs WJ, Özcan F, Keller F, Beige J, Wagner K, Helmchen U, Noriega M, Wiech T, Panzer U, Stahl RA
    J Am Soc Nephrol. 2015
  • Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
    Meyer-Schwesinger C, Lambeau G, Stahl RA
    N Engl J Med. 2015

PD Dr. med. Elion Hoxha

Project Leader B1

Medical Specialist for Internal Medicine and Nephrology
Consultant (Oberarzt)
III. Department of Medicine, UKE Hamburg

Telefone +49 (0) 40 7410 - 58817
Telefax +49 (0) 40 7410 - 49017
E-Mail This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine at the University Hamburg
  • Study of Molecular Biology at the Centre of Molecular Neurobiology Hamburg
  • M.D. thesis at the Institute for Biochemistry and Molecular Biology, UKE
  • Assistant Physician at the III. Department of Medicine, UKE
  • Grant from the Werner Otto Stiftung
  • Gerok Position at the Clinical Research Unit 228 “Immunopathogenesis and Therapy of Glomerulonephritis”
  • Co-Applicant in Project 6 of the Clinical Research Unit 228 “Immunopathogenesis and Therapy of Glomerulonephritis”
  • Project leader of Project B1 of the CRC 1192: Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications
  • Board Certification (Facharzt) in Nephrology and Internal Medicine
  • Habilitation in Nephrology and Internal Medicine
  • Else Kröner Exzellenzstipendium (Fellowship)
  • Consultant (Oberarzt) at the III. Department of Medicine, UKE
  • Heisenberg-Program of the Deutsche Forschungsgemeinschaft
Awards

• Scholarship of the University of Hamburg (2004)
• „Best abstracts“ at the XLVII ERA-EDTA Congress (2010)
• „Best oral presentations“ at the DGfN Congress (2012)
• Heinrich Nether Promotion Price for Molecular Biology (2010)
• Nils-Alwall-Award of the German Society of Nephrology (2016)
• Teacher of the Year 2018

Publications during the first funding period of the SFB 1192

  • Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy.

    Mahmud M, Pinnschmidt HO, Reinhard L, Harendza S, Wiech T, Stahl RAK, Hoxha E PLoS One. 2019 Sep

  • Diagnostic role of renal biopsy in PLA2R1-antibody-positive patients with nephrotic syndrome.

    Wiech T, Stahl RAK, Hoxha E Mod Pathol. 2019 Sep

  • Bevacizumab-associated glomerular microangiopathy.

    Person F, Rinschen M, Brix S, Wulf S, Noriega M, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz O, Reinhard L, Hoxha E, Zipfel P, Bräsen J, Wiech TMod Pathol. 2018 Dec

  • Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

    von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAKFront Immunol. 2018 Dec

  • Characterization of Autoantibodies in Primary Membranous Nephropathy and their clinical Significance.

    Stahl RAK, Reinhard L, Hoxha E.Expert Rev Clin Immunol. 2018 Nov

  • Genetics of membranous nephropathy.

    Gupta S, Köttgen A, Hoxha E, Brenchley P, Bockenhauer D, Stanescu HC, Kleta R.Nephrol Dial Transplant. 2018 Sep

  • The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

    Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

  • Immunohistochemical and serological characterization of membranous nephropathy in children and adolescents

    Dettmar A, Wiech T, Kemper M, Soave A, Rink M, Oh J, Stahl R, Hoxha E Pediatr Nephrol. 2018 Mar

  • A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

    Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

  • Translational Aspects of Primary Membranous Nephropathy.

    Hoxha E, Stahl RAK.Semin Nephrol. 2017 Sep

  • Membranous nephropathy-one morphologic pattern with different diseases

    Hoxha E, von Haxthausen F, Wiech T, Stahl RPflugers Arch. 2017 Aug

  • THSD7A expression in human cancer

    Stahl P, Hoxha E, Wiech T, Schröder C, Simon R, Stahl R Genes Chromosomes Cancer. 2017 Apr

  • An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

    Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

  • Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

    Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

  • A Mechanism for Cancer-Associated Membranous Nephropathy. 

    Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

Further selected Publications
  • Spontaneous remission of proteinuria is a frequent event in phospholipase A2 receptor antibody negative patients with membranous nephropathy.
    Hoxha E, Harendza S, Pinnschmidt HO, Tomas NM, Helmchen U, Panzer U, Stahl RA.
    Nephrol Dial Transplant. 2015
  • CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.
    Brix SR, Stege G, Disteldorf E, Hoxha E, Krebs C, Krohn S, Otto B, Klätschke K, Herden E, Heymann F, Lira SA, Tacke F, Wolf G, Busch M, Jabs WJ, Özcan F, Keller F, Beige J, Wagner K, Helmchen U, Noriega M, Wiech T, Panzer U, Stahl RA
    J Am Soc Nephrol. 2015
  • PLA2R antibody levels and clinical outcome in patients with membranous nephropathy and non-nephrotic range proteinuria under treatment with inhibitors of the renin-angiotensin system.
    Hoxha E, Harendza S, Pinnschmidt H, Panzer U, Stahl RAK.
    PLoS One. 2014
  • Rituximab treatment for relapsing minimal change disease and focal segmental glomerulosclerosis: a systematic review.
    Kronbichler A, Kerschbaum J, Fernandez-Fresnedo G, Hoxha E, Kurschat CE, Busch M, Bruchfeld A, Mayer G, Rudnicki M.
    Am J Nephrol. 2014
  • Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
    Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
    N Engl J Med. 2014
  • M-type phospholipase A2 receptor autoantibodies and renal function in patients with primary membranous nephropathy.
    Hoxha E, Harendza S, Pinnschmidt H, Panzer U, Stahl RA
    Clin J Am Soc Nephrol. 2014
  • Phospholipase A2 Receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy.
    Hoxha E, Thiele I, Zahner G, Panzer U, Harendza S, Stahl RA
    J Am Soc Nephrol. 2014
  • Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy.
    Dähnrich C, Komorowski L, Probst C, Seitz-Polski B, Esnault V, Wetzels JF, Hofstra JM, Hoxha E, Stahl RA, Lambeau G, Stöcker W, Schlumberger W.
    Clin Chim Acta. 2013
  • Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.
    Hoxha E, Kneißler U, Stege G, Zahner G, Thiele I, Panzer U, Harendza S, Helmchen U, Stahl RAK.
    Kidney Int. 2012
  • Renal IL-17 expression in human ANCA-associated glomerulonephritis.
    Velden J, Paust HJ, Hoxha E, Turner JE, Steinmetz OM, Wolf G, Jabs WJ, Özcan F, Beige J, Heering PJ, Schröder S, Kneißler U, Disteldorf E, Mittrücker HW, Stahl RA, Helmchen U, Panzer U.
    Am J Physiol Renal Physiol. 2012
  • An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis.
    Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl RA
    Nephrol Dial Transplant. 2011
  • Rituximab in adult patients with immunosuppressive-dependent minimal change disease.
    Hoxha E, Stahl RAK, Harendza S.
    Clin Nephrol. 2011
  • Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
    Meyer-Schwesinger C, Sievert H, Meyer TN, Hoxha E, Sachs M, Klupp E-M, Münster S, Balabanov S, Carrier L, Helmchen U, Thaiss F, Stahl RAK.
    Am J Pathol. 2011
  • Posttranscriptional regulation of the p85a adapter subunit of Phosphatidylinositol 3-kinase in human leukemia cells.
    Hoffmann BT, Hoxha E, Mohr E, Schulz K, Jücker M.
    Leuk Lymphoma. 2011
  • PLA2R Autoantibodies and recurrent membranous nephropathy after transplantation.
    Stahl RAK, Hoxha E, Fechner K.
    N Engl J Med. 2010

Prof. Dr. rer. nat. Gisa Tiegs

Project Leader A2

Leader of the Institute of Experimental Immunology and Hepatology, UKE Hamburg

Telefone +49 (0) 40 7410 - 58731
Telefax +49 (0) 40 7410 - 57150
E-Mail This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career

• Study of Chemistry, University of Frankfurt/Main
• Study of Biochemistry, University of Tübingen
• Ph.D. thesis, Institute of Physiological Chemistry, University of Tübingen
• Research Assistant and Assistant Lecturer at the Department of Biochemical Pharmacology, University of Constance
• Habilitation in Pharmacology and Toxicology, University of Constance
• Professor of Experimental Toxicology at the Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Erlangen-Nürnberg
• Professor and Chair of the Institute of Experimental Immunology and Hepatology, UKE
• Chair of Pharmacology & Toxicology, Univ. of Regensburg, rejected

Awards

• Hans Popper “Förderpreis” for the best experimental work with clinical reference in the field of hepatology
• Sandoz-Preis for therapy-relevant pharmacological research

Publications during the first funding period of the SFB 1192

  • Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T-cell responses.

    Breda PC, Wiech T, Meyer-Schwesinger C, Grahammer F, Huber TB, Panzer U, Tiegs G, Neumann K.Am J Physiol Renal Physiol. 2019 Apr

  • The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.

    Neumann K, Ostmann A, Breda PC, Ochel A, Tacke F, Paust HJ, Panzer U, Tiegs G Sci Rep. 2019 Feb

  • IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

    Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

  • RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

    Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

  • T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

    Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

  • RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

    Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

    Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

Further selected Publications
  • Deletion of tumour necrosis factor α receptor 1 elicits an increased TH17 immune response in the chronically inflamed liver.
    Berkhout L, Barikbin R, Schiller B, Ravichandran G, Krech T, Neumann K, Sass G, Tiegs G
    Sci Rep. 2019
  • Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice.
    Horst AK*, Wegscheid C*, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert AE, Oldhafer KJ, Weiler-Normann C, Lang KS, Singer BB, Altfeld M, Diehl L, Tiegs G
    Hepatology. 2018
  • A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis.
    Neumann K*, Karimi K*, Meiners J, Voetlause R, Steinmann S, Dammermann W, Lüth S, Asghari F, Wegscheid C, Horst A, Tiegs G
    J Immunol. 2017
  • Regulatory T cell-derived interleukin-10 ameliorates crescentic glomerulonephritis.
    Ostmann A, Paust HJ, Panzer U, Wegscheid C, Kapffer S, Huber S, Flavell RA, Erhardt A, Tiegs G
    J Am Soc Nephrol. 2013
  • Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
    Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
    J Immunol. 2013
  • Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
    Paust HJ, Ostmann A, Erhardt A, Turner JE, Velden J, Mittrücker HW, Sparwasser T, Panzer U, Tiegs G.
    Kidney Int. 2011
  • CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis.
    Erhardt A, Wegscheid C, Claass B, Carambia A, Herkel J, Mittrücker HW, Panzer U, Tiegs G
    J Immunol. 2011
  • Autonomic renal denervation ameliorates experimental GN.
    Veelken R, Vogel EM, Hilgers K, Amann K, Hartner A, Sass G, Neuhuber W, Tiegs G
    J Am Soc Nephrol. 2008

Dr. med. Nicola M. Tomas

Project Leader B2

Resident
III. Department of Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 18485
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific Career
  • Study of Medicine at the University of Witten/Herdecke
  • M.D. thesis at the Institute of Immunology, University Witten/Herdecke; summa cum laude
  • United states medical licensing examination (USMLE)
  • Assistant Physician at the III. Medizinische Klinik, UKE
  • Gerok Position at the Clinical Research Unit 228 “Immunopathogenesis and Therapy of Glomerulonephritis”
  • Postdoctoral fellowship at the Institute of Molecular and Cellular Pharmacology, University of Nice/Sophia Antipolis, France
  • Project leader Emmy Noether Research Group “Molecular Mechanisms of Membranous
Awards
  • Dr.-Martini-Preis der Dr.-Martini-Stiftung in Hamburg (2017)
Publications during the first funding period of the SFB 1192

  • The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

    Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

  • A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

    Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

  • An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

    Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

  • Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

    Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

  • A Mechanism for Cancer-Associated Membranous Nephropathy. 

    Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

Further selected Publications
  • Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
    Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
    N Engl J Med. 2014
  • Phospholipase A2 Receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy.
    Hoxha E, Thiele I, Zahner G, Panzer U, Harendza S, Stahl RA
    J Am Soc Nephrol. 2014

  • Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis.
    Kluger MA, Zahner G, Paust HJ, Schaper M, Magnus T, Panzer U, Stahl RA
    Kidney Int. 2013

  • Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.
    Hoxha E, Kneißler U, Stege G, Zahner G, Thiele I, Panzer U, Harendza S, Helmchen UM, Stahl RA
    Kidney Int. 2012

  • An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis.
    Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl RA
    Nephrol Dial Transplant. 2011

  • Prostaglandin EP2 and EP4 receptors modulate expression of the chemokine CCL2 (MCP-1) in response to LPS-induced renal glomerular inflammation.
    Zahner G, Schaper M, Panzer U, Kluger M, Stahl RA, Thaiss F, Schneider A
    Biochem J. 2009

  • 15-Deoxy-∆12,14-prostaglandin J2 inhibits INF-gamma- induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells.
    Panzer U*, Zahner G*, Wienberg U, Steinmetz OM, Peters A, Turner JE, Paust HJ,
    Wolf G, Stahl RA, Schneider A *contributed equally
    Nephrol Dial Transplant. 2008

  • Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell
    proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase
    inhibitors p21waf/cip-1 and p27kip-1.
    Zahner G, Wolf G, Ayoub M, Reinking R, Panzer U, Shankland SJ, Stahl RA
    J Biol Chem. 2002

  • Prostaglandin E2 stimulates expression of matrix metalloproteinase 2 in cultured rat mesangial cells.
    Zahner G, Harendza S, Müller E, Wolf G, Thaiss F, Stahl RA
    Kidney Int. 1997

PD Dr. rer. nat. Gunther Zahner

Project Leader B2

III. Department of Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 53936
Fax  +49 (0) 40 7410 - 59036
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Biology, University Stuttgart
  • Ph.D. thesis, Division of Nephrology, University Frankfurt
  • Postdoc and Laboratory Manager, III. Medizinische Klinik, UKE
  • Habilitation in Experimental Medicine, University Hamburg
Publications during the first funding period of the SFB 1192

  • The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

    Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

  • A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

    Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

  • An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

    Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

  • Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

    Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

  • A Mechanism for Cancer-Associated Membranous Nephropathy. 

    Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

Further selected Publications
  • Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
    Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
    N Engl J Med. 2014
  • Phospholipase A2 Receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy.
    Hoxha E, Thiele I, Zahner G, Panzer U, Harendza S, Stahl RA
    J Am Soc Nephrol. 2014

  • Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis.
    Kluger MA, Zahner G, Paust HJ, Schaper M, Magnus T, Panzer U, Stahl RA
    Kidney Int. 2013

  • Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.
    Hoxha E, Kneißler U, Stege G, Zahner G, Thiele I, Panzer U, Harendza S, Helmchen UM, Stahl RA
    Kidney Int. 2012

  • An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis.
    Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl RA
    Nephrol Dial Transplant. 2011

  • Prostaglandin EP2 and EP4 receptors modulate expression of the chemokine CCL2 (MCP-1) in response to LPS-induced renal glomerular inflammation.
    Zahner G, Schaper M, Panzer U, Kluger M, Stahl RA, Thaiss F, Schneider A
    Biochem J. 2009

  • 15-Deoxy-∆12,14-prostaglandin J2 inhibits INF-gamma- induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells.
    Panzer U*, Zahner G*, Wienberg U, Steinmetz OM, Peters A, Turner JE, Paust HJ,
    Wolf G, Stahl RA, Schneider A *contributed equally
    Nephrol Dial Transplant. 2008

  • Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell
    proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase
    inhibitors p21waf/cip-1 and p27kip-1.
    Zahner G, Wolf G, Ayoub M, Reinking R, Panzer U, Shankland SJ, Stahl RA
    J Biol Chem. 2002

  • Prostaglandin E2 stimulates expression of matrix metalloproteinase 2 in cultured rat mesangial cells.
    Zahner G, Harendza S, Müller E, Wolf G, Thaiss F, Stahl RA
    Kidney Int. 1997

Prof. Dr. med. Oliver Steinmetz

Project Leader A3

Senior Physician
Medical Specialist in Internal Medicine and Nephrology
III. Department of Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 54167
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine at the University of Cologne and Hamburg
  • M.D. thesis in the Centre for Molecular Neurobiology, Hamburg (ZMNH)
  • Assistant Physician at the III. Medizinische Klinik, UKE
  • Postdoc at the Centre for Inflammatory Diseases, Monash, Australia
  • Clinical Specialization in Internal Medicine and Nephrology
  • Habilitation in Internal Medicine, University of Hamburg
  • Consultant (Oberarzt) at the III. Medizinische Klinik, UKE
  • aPL Professorship
Awards
  • Hans-U.-Zollinger-Research-Award of the German Society of Nephrology (2015)
  • Braun´s Award for Internal Medicine (2015)
Publications during the first funding period of the SFB 1192

  • A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt+Foxp3+ Tregs with Enhanced Suppressive Capacity.

    Hagenstein J, Melderis S, Nosko A, Warkotsch MT, Richter JV, Ramcke T, Herrnstadt GR, Scheller J, Yan I, Mittrücker HW, Kluger MA, Steinmetz OM. J Am Soc Nephrol. 2019 Aug

  • Bevacizumab-associated glomerular microangiopathy.

    Person F, Rinschen M, Brix S, Wulf S, Noriega M, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz O, Reinhard L, Hoxha E, Zipfel P, Bräsen J, Wiech TMod Pathol. 2018 Dec

  • Lupusnephritis

    Melderis S, Wiech T, Iking-Konert C, Steinmetz OZ Rheumatol. 2018 Sep

  • IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

    Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

  • Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

    Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

  • IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

    Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

  • RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

    Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

  • T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

    Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

  • CD4+ T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes.

    Krebs CF, Steinmetz OM.Mediators Inflamm. 2016

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

  • Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

    Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

  • A Mechanism for Cancer-Associated Membranous Nephropathy. 

    Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

  • IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

    Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

  • RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

    Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

    Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

Further selected Publications
  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
    Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
    Kidney Int. 2016

  • RORγt+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN
    Kluger M, Meyer M, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
    J Am Soc Nephrol. 2016

  • Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
    Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RAK, Panzer U, Steinmetz OM:
    J Am Soc Nephrol. 2015

  • Stat3 Programs Th17-Specific Regulatory T Cells to Control GN.
    Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix S, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM
    J Am Soc Nephrol. 2014
  • B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis.
    Kluger MA, Ostmann A, Luig M, Meyer MC, Goerke B, Paust HJ, Meyer-Schwesinger C, Stahl RA, Panzer U, Tiegs G, Steinmetz OM
    Eur J Immunol. 2014

  • Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
    Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B
    Nat Immunol. 2013

  • The Th17-defining transcription factor RORγt promotes glomerulonephritis.
    Steinmetz OM, Summers SA, Gan PY, Semple T, Holdsworth SR, Kitching AR
    J Am Soc Nephrol. 2011

PD Dr. med. Malte Kluger

Project Leader A3

Medical Specialist in Internal Medicine and Nephrology
Consultant (Oberarzt)
III. Department of Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 0
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine at the Universität Hamburg
  • M.D. thesis at the III. Medizinische Klinik, UKE
  • Assistent Physician at the III. Medizinische Klinik, UKE
  • Research scholarship from the medical faculty at the UKE (FFM-program)
  • DAAD-geförderter Forschungsaufenthalt im Center for Inflammatory Diseases in Melbourne/Australia
  • Facharzt für Innere Medizin und Nephrologie
  • Clinician Scientist program, UKE
  • Habilitation in Innere Medizin/Nephrologie, Universität Hamburg
  • Stipent of the Deutsche Gesellschaft für Nephrologie and Deutsche Nierenstiftung
  • Consultant (Oberarzt) at the III. Medizinische Klinik, UKE
  • Research coordinator of the Universitäre Transplantations Centrum (UTC), UKE
Publications during the first funding period of the SFB 1192

  • A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt+Foxp3+ Tregs with Enhanced Suppressive Capacity.

    Hagenstein J, Melderis S, Nosko A, Warkotsch MT, Richter JV, Ramcke T, Herrnstadt GR, Scheller J, Yan I, Mittrücker HW, Kluger MA, Steinmetz OM. J Am Soc Nephrol. 2019 Aug

  • IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

    Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

  • RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

    Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

  • T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

    Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

  • IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

    Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

  • RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

    Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

    Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

Further selected Publications
  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
    Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
    Kidney Int. 2016

  • RORγt+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN
    Kluger M, Meyer M, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
    J Am Soc Nephrol. 2016

  • Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
    Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RAK, Panzer U, Steinmetz OM:
    J Am Soc Nephrol. 2015

  • Stat3 Programs Th17-Specific Regulatory T Cells to Control GN.
    Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix S, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM
    J Am Soc Nephrol. 2014
  • B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis.
    Kluger MA, Ostmann A, Luig M, Meyer MC, Goerke B, Paust HJ, Meyer-Schwesinger C, Stahl RA, Panzer U, Tiegs G, Steinmetz OM
    Eur J Immunol. 2014

Prof. Dr. med. Catherine Meyer-Schwesinger

Project Leader B3

Institute of Cellular and Integrative Physiology, UKE Hamburg

Phone  +49 (0) 04 7410 - 57560
Phone  +49 (0) 40 7410 - 51558
Fax  +49 (0) 40 7410 - 59299
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Studies of Medicine at the University of Freiburg
  • Doctorate (Dr. med) at the University of Freiburg and the Harvard
  • Medical School, Boston, USA; summa cum laude
  • Postdoctoral fellow at the department of nephrology at the University of California, San Diego
  • Research assistant at the department of medicine, nephrology at the University of Hamburg-Eppendorf
  • Habilitation in Experimental Medicine, University Hamburg
  • Heisenberg Stipend
  • W3 Heisenberg professorship in the Institute of Cellular and Integrative Physiology, at the University of Hamburg-Eppendorf
Awards
  • Dr. Martinipreis, UKE Hamburg-Eppendorf

Publications during the first funding period of the SFB 1192

  • The Ubiquitin Proteasome System in Kidney Physiology and Disease.

    Meyer-Schwesinger CNat Rev Nephrol. 2019 Apr

  • Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T-cell responses.

    Breda PC, Wiech T, Meyer-Schwesinger C, Grahammer F, Huber TB, Panzer U, Tiegs G, Neumann K.Am J Physiol Renal Physiol. 2019 Apr

  • Thrombospondin Type 1 Domain-Containing 7A (THSD7A) Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes.

    Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger CJ Am Soc Nephrol. 2019 Apr

  • Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

    Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

  • Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.

    Reinicke, AT, Laban, K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch CP, Duncan KE, Saftig P, Rischen MM, Morellini F, Meyer-Schwesinger CProc Natl Acad Sci U S A. 2019 Mar

  • Protecting the kidney against autoimmunity and inflammation.

    Christian Kurts, Catherine Meyer-SchwesingerNat Rev Nephrol. 2018 Dec

  • The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

    Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

  • Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

    Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

  • A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

    Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

  • IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

    Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

  • An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

    Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

  • Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. 

    Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte FSci Transl Med. 2016 Nov

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

    Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

  • The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

    Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

  • A Mechanism for Cancer-Associated Membranous Nephropathy. 

    Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

  • The Role of Renal Progenitors in Renal Regeneration

    Meyer-Schwesinger C Nephron. 2016

  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

    Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

Further selected Publications
  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
    Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
    Kidney Int. 2016

  • The Role of Renal Progenitors in Renal Regeneration
    Meyer-Schwesinger C
    Nephron. 2016

  • MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype.
    Kietzmann L*, Guhr SS*, Meyer TN, Ni L, Sachs M, Panzer U, Stahl RA, Saleem MA, Kerjaschki D, Gebeshuber CA* and Meyer-Schwesinger C*. *contributed equally
    J Am Soc Nephrol. 2015

  • Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
    Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
    N Engl J Med. 2014

  • UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.
    Lohmann F, Sachs M, Meyer TN, Sievert H, Lindenmeyer MT, Wiech T, Cohen CD, Balabanov S, Stahl RAK, Meyer-Schwesinger C
    Biochim Biophys Acta. 2014

  • Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases.
    Beeken M*, Lindenmeyer MT*, Blattner SM*, Radón V*, Oh J, Meyer TN, Hildebrand D, Schlüter H, Reinicke AT, Knop JH, Vivekanandan-Giri A, Münster S, Sachs M, Wiech T, Pennathur S, Cohen CD, Kretzler M, Stahl RAK, Meyer-Schwesinger C. *contributed equally
    J Am Soc Nephrol. 2014

  • Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium.
    Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ, Garbi N, Kastenmüller W, Knolle PA, Kurts C*, Engel DR*. *contributed equally
    Cell. 2014

  • The expression of podocyte-specific proteins in parietal epithelial cells is regulated by protein degradation.
    Guhr SS, Sachs M, Wegner A, Becker JU, Meyer TN, Kietzmann L, Schlossarek S, Carrier L, Braig M, Jat PS, Stahl RA, Meyer-Schwesinger C.
    Kidney Int. 2013

Prof. Dr. rer. nat. Hans-Willi Mittrücker

Project Leader A4
Institute for Immunology, UKE Hamburg

Phone  +49 (0) 40 7410 - 57922
Fax  +49 (0) 40 7410 - 54243
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Biology at the University of Mainz
  • Diploma thesis, 1st Department of Medicine, Section Pathophysiology University of Mainz
  • Ph.D. thesis, 1st Department of Medicine, Section Pathophysiology University of Mainz
  • Postdoc in the Department of Immunology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg
  • Postdoc at the Ontario Cancer Institute, Toronto, Canada
  • Group leader in the Division of Immunology, Max-Planck-Institute for Infection Biology, Berlin
  • Habilitation in Immunology and Medical Microbiology at the Free University of Berlin
  • W2 Professor at the Institute for Immunology, UKE Hamburg
Publications during the first funding period of the SFB 1192

  • A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt+Foxp3+ Tregs with Enhanced Suppressive Capacity.

    Hagenstein J, Melderis S, Nosko A, Warkotsch MT, Richter JV, Ramcke T, Herrnstadt GR, Scheller J, Yan I, Mittrücker HW, Kluger MA, Steinmetz OM. J Am Soc Nephrol. 2019 Aug

  • The role of regulatory T cells in Experimental Autoimmune Glomerulonephritis.

    Klinge S, Yan K, Reimers D, Brede KM, Schmid J, Paust HJ, Krebs CF, Panzer U, Hopfer H, Mittrücker H-W. Am J Physiol Renal Physiol 2019 Mar

  • Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice.

    Rosendahl A, Kabiri R, Bode M, Cai A, Klinge S, Ehmke H, Mittrücker HW, Wenzel UOBr J Pharmacol. 2018 Sep

  • Tissue-Resident Lymphocytes in the Kidney. 

    Turner JE, Becker M, Mittrücker HW, Panzer UJ Am Soc Nephrol. 2018 Feb

  • Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling.

    Dixit A, Bottek J, Beerlage AL, Schuettpelz J, Thiebes S, Brenzel A, Garbers C, Rose-John S, Mittrücker H-W, Squire A, Engel DR.J Leukoc Biol. 2018 Jan

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

Further selected Publications
  • Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism.
    Mahnke J, Schumacher V, Ahrens S, Käding N, Feldhoff LM, Huber M, Rupp J, Raczkowski F, Mittrücker H-W
    Sci Rep. 2016

  • ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.
    Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker H-W*, Chalaris A*. *contributed equally
    J Leukoc Biol. 2016

  • CXCR3+ regulatory T cells control TH1 responses in crescentic GN.
    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H-W, Steinmetz OM, Stahl RA, Panzer U.
    J Am Soc Nephrol. 2016

  • TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis.
    Hünemörder S, Treder J, Ahrens S, Schumacher V, Paust HJ, Menter T, Matthys P, Kamradt T, Meyer-Schwesinger C, Panzer U, Hopfer H, Mittrücker H-W (2015).
    J Pathol. 2015

  • Glomerulopathy induced by immunization with a peptide derived from the Goodpasture antigen α3IV-NC1.
    Hopfer H, Hünemörder S, Treder J, Turner J-E, Paust H-J, Meyer-Schwesinger C, Hopfer U, Sachs M, Peters A, Bucher-Kocaoglu B, Ahrens S, Panzer U, Mittrücker H-W (2015).
    J Immunol. 2015

  • CXCL5 drives neutrophil recruitment in TH17-mediated GN.
    Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U.
    J Am Soc Nephrol. 2015

  • The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
    Raczkowski F, Ritter J, Heesch K, Schumacher V, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker H-W*, Huber M*. (*contributed equally)
    Proc Natl Acad Sci U S A. 2013

  • Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis.
    Hopfer H, Holzer J, Hünemörder S, Paust HJ, Sachs M, Meyer-Schwesinger C, Turner JE, Panzer U, Mittrücker H-W
    Kidney Int. 2012

PD Dr. med. Christian F. Krebs

Project Leader A5

Consultant (Oberarzt)
Clinical Specialization in Internal Medicine and Nephrology
III. Department of Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 53717
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine at the Universities of Göttingen and Hamburg
  • M.D. thesis at the Institut für Immunologie, summa cum laude
  • Clinical Specialization in Internal Medicine and Nephrology
  • Research scholarship from the medical faculty at the UKE
  • Stipent of the Deutsche Gesellschaft für Nephrologie and Deutsche Nierenstiftung
  • Habilitation in Internal Medicine and Nephrology, University Hamburg
  • Consultant (Oberarzt), III. Medizinische Klinik, Translationale Immunologie, UKE
Awards
  • Medac-Award for Immunology (doctoral thesis) (2006)
  • Adalbert-Buding-Award from the Deutsche Hochdruckliga (2011)
  • Dr.-Martini-Preis of the Dr.-Martini-Stiftung in Hamburg (2014)
  • Hans-U.-Zollinger-Research-Award of the German Society of Nephrology (2017)
Publications during the first funding period of the SFB 1192

  • Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells.

    Likai Tan, Inga Sandrock, Ivan Odak, Yuval Aizenbud, Anneke Wilharm, Joana Barros-Martins, Yaara Tabib, Alina Borchers, Tiago Amado, Lahiru Gangoda, Marco J. Herold, Marc Schmidt-Supprian, Jan Kisielow, Bruno Silva-Santos, Christian Koenecke, Avi-Hai Hovav, Christian Krebs, Immo Prinz, Sarina Ravens Cell Rep. 2019 Jun

  • The role of regulatory T cells in Experimental Autoimmune Glomerulonephritis.

    Klinge S, Yan K, Reimers D, Brede KM, Schmid J, Paust HJ, Krebs CF, Panzer U, Hopfer H, Mittrücker H-W. Am J Physiol Renal Physiol 2019 Mar

  • Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

    Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson J, Antonson P, Roncarolo M, Villablanca E, Gagliani N, Huber SNat Commun. 2018 Dec

  • IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

    Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

  • T helper type 17 cells in immune-mediated glomerular disease

    Krebs C, Schmidt T, Riedel J, Panzer U Nat Rev Nephrol. 2017 Oct

  • IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.

    Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S.J Immunol. 2017 Feb

  • CD4+ T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes.

    Krebs CF, Steinmetz OM.Mediators Inflamm. 2016

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

  • Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

    Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

  • IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

    Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

  • Immune Mechanisms in Arterial Hypertension

    Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

Further selected Publications
  • CXCL5 drives neutrophil recruitment in TH17-mediated GN.
    Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U.
    J Am Soc Nephrol. 2015

  • Micro-RNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN.
    Krebs CF, Kapffer S, Paust HJ, Schmidt T, Bennstein SB, Peters A, Stege G, Brix SR, Meyer-Schwesinger C, Müller RU, Turner JE, Steinmetz OM, Wolf G, Stahl RA, Panzer U
    J Am Soc Nephrol. 2013

  • Immature renal DC recruit regulatory CXCR6+ iNKT cells to attenuate crescentic GN.
    Riedel JH, Paust HJ, Turner JE, Tittel AP, Krebs C, Disteldorf E, Tiegs G, Velden J, Mittrücker HW, Garbi N, Stahl RA, Steinmetz OM, Kurts C, Panzer U
    J Am Soc Nephrol. 2012

  • CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.
    Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F.
    J Immunol. 2005

  • NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.
    Seman M, Adriouch S, Scheuplein F, Krebs C, Freese D, Glowacki G, Deterre P, Haag F, Koch-Nolte F.
    Immunity. 2003

Prof. Dr. med. Samuel Huber

Project Leader A5

Head, Section  of Molecular Immunology and Gastroenterology
Consultant (Oberarzt)
Medical specialist for Internal Medicine and Gastroenterology
I. Department of Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 20982
Fax  +49 (0) 40 7410 - 59038
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine, University Ulm, Heidelberg, and Mainz
  • M.D. thesis, I. Medizinische Klinik, Universität Mainz
  • Assistant Physician at the I. Medizinische Klinik, UKE
  • Postdoctoral fellow/ research affiliate at the Department of Immunobiology, Yale University, School of Medicine
  • Research group leader, I. Medizinische Klinik, UKE
  • Peter Hans Hofschneider Professor (W2) of Molecular Immunology and Gastroenterology at the I. Medizinische Klinik, UKE
  • Senior Physician (Oberarzt) at the I. Medizinische Klinik
  • Heisenberg Professor (W3) of Intestinal Immune Regulation
Awards
  • Dr.-Martini Award from the Dr.-Martini Foundation, Germany (2009)
  • Postdoctoral research fellowship award from the Crohns and Colitis foundation of America (2011)
  • Ernst Jung-Karriere-Förderpreis from the Ernst Jung Foundation, Germany (2012)
  • Dr.-Liselotte-Brauns Award from the Liselotte-Brauns Foundation, Germany (2013)
  • Theodor-Frerichs Award from the German association for Internal Medicine (DGIM), Germany (2017)
Publications during the first funding period of the SFB 1192

  • Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

    Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

  • Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

    Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson J, Antonson P, Roncarolo M, Villablanca E, Gagliani N, Huber SNat Commun. 2018 Dec

  • IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

    Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OMJ Am Soc Nephrol. 2018

  • IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.

    Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S.J Immunol. 2017 Feb

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

    Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

Further selected Publications
  • A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.
    Pelczar, P., M. Witkowski, L. G. Perez, J. Kempski, A. G. Hammel, L. Brockmann, D. Kleinschmidt, S. Wende, C. Haueis, T. Bedke, M. Witkowski, S. Krasemann, S. Steurer, C. J. Booth, P. Busch, A. Konig, U. Rauch, D. Benten, J. R. Izbicki, T. Rosch, A. W. Lohse, T. Strowig, N. Gagliani*, R. A. Flavell*, and S. Huber*. *contributed equally
    Science. 2016

  • Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
    Gagliani, N., M. C. Amezcua Vesely, A. Iseppon, L. Brockmann, H. Xu, N. W. Palm, M. R. de Zoete, P. Licona-Limon, R. S. Paiva, T. Ching, C. Weaver, X. Zi, X. Pan, R. Fan, L. X. Garmire, M. J. Cotton, Y. Drier, B. Bernstein, J. Geginat, B. Stockinger, E. Esplugues, S. Huber*, and R. A. Flavell*. *contributed equally
    Nature. 2015

  • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.
    Gagliani N*, Magnani CF*, Huber S*, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A, Trentini F, Di Serio C, Bacchetta R, Andreani M, Brockmann L, Gregori S, Flavell RA, Roncarolo MG. *contributed equally
    Nat Med. 2013

  • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
    Huber S*, Gagliani N*, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O’Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA *contributed equally
    Nature. 2012

  • Control of TH17 cells occurs in the small intestine.
    Esplugues E*, Huber S*, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor WJr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. *contributed equally
    Nature. 2011

  • Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
    Huber S*, Gagliani N*, Esplugues E*, O'Connor WJr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. *contributed equally
    Immunity. 2011

Prof. Dr. med. Friedrich Koch-Nolte

Project Leader B5

Institute for Immunology, UKE Hamburg

Phone  +49 (0) 40 7410 - 53612
Fax  +49 (0) 40 7410 - 54243
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Scientific career
  • Study of Biology, Lehigh and Wesleyan Universities, USA
  • Bachelor of Arts in Biology, Wesleyan University
  • Study of Medicine, Universities of Hamburg and Tübingen
  • MD Thesis, University of Tübingen
  • Study of Molecular Biology, University of Hamburg
  • Habilitation and venia legendi in Immunology and Mol. Biology, UKE
  • Sabbatical at The Jackson Lab, Bar Harbor, ME
  • Sabbatical at the University of California at San Francisco, CA
  • Professor of Immunology and Molecular Biology, University of Hamburg
  • Sabbatical at the DNAX Research Institute, Palo Alto, CA
  • Sabbatical at the The Jackson Lab, Bar Harbor, ME
  • Deputy Director, Institute of Immunology, UKE
  • Sabbatical at the Université Rouen, France
Awards
  • Martini-Prize (1990)
  • Prize of the Werner-Otto foundation (1999)
  • Prize for Mentorship of the Claussen-Simon foundation (2009)
Publications during the first funding period of the SFB 1192

  • Purine Release, Metabolism, and Signaling in the Inflammatory Response.

    Linden J, Koch-Nolte F, Dahl G.Annu Rev Immunol. 2019 Jan

  • T RM maintenance is regulated by tissue damage via P2RX7.

    Stark R, Wesselink TH, Behr FM, Kragten NAM, Arens R, Koch-Nolte F, van Gisbergen KPJM, van Lier RAW.Sci Immunol. 2018 Dec

  • CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.

    Schütze K, Petry K, Hambach J, Schuster N, Fumey W, Schriewer L, Röckendorf J, Menzel S, Albrecht B, Haag F, Stortelers C, Bannas P, Koch-Nolte F.Front Immunol. 2018 Nov

  • Monitoring the Sensitivity of T Cell Populations Towards NAD+ Released During Cell Preparation.

    Rissiek B, Lukowiak M, Haag F, Magnus T, Koch-Nolte F.Methods Mol Biol. 2018 Aug

  • Modulating ion channel function with antibodies and nanobodies.

    Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F.Curr Opin Immunol. 2018 Jun

  • The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

    Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NMJ Am Soc Nephrol. 2018 May

  • Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity.

    Menzel S, Schwarz N, Haag F, Koch-Nolte F.Front Pharmacol. 2018 Mar

  • A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

    Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R J Am Soc Nephrol. 2017 Nov

  • Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. 

    Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte FSci Transl Med. 2016 Nov

  • Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. 

    Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.J Clin Invest. 2016 Jul

Further selected Publications
  • Trm maintenance is regulated by tissue damage via P2RX7.
    Stark R, Wesselink TH, Behr FM, Kragten NAM, Arens R, Koch-Nolte F, van Gisbergen KPJM, van Lier RAW
    Sci Immunol. 2018

  • Modulating ion channel function with antibodies and nanobodies.
    Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F.
    Curr Opin Immunol. 2018

  • A cDNA immunization strategy to generate nanobodies against membrane proteins in native conformation.
    Eden T, Menzel S, Wesolowski J, Bergmann P, Nissen M, Dubberke G, Seyfried F, Albrecht B, Haag F, Koch-Nolte F.
    Front Immunol. 2018

  • Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.
    Fumey W, Koenigsdorf J, Kunick V, Menzel S, Schütze K, Unger M, Schriewer L, Haag F, Adam G, Oberle A, Binder M, Fliegert R, Guse A, Zhao YJ, Cheung Lee H, Malavasi F, Goldbaum F, van Hegelsom R, Stortelers C, Bannas P, Koch-Nolte F
    Sci Rep. 2017

  • NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells.
    Scheuplein F, Schwarz N, Adriouch S, Krebs C, Bannas P, Rissiek B, Seman M, Haag F, Koch-Nolte F
    J Immunol. 2009

  • NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.
    Seman M, Adriouch S, Scheuplein F, Krebs C, Freese D, Glowacki G, Deterre P, Haag F, Koch-Nolte F.
    Immunity. 2003

PD. Dr. med. Jan-Eric Turner

Project Leader A6

Projectleader of the Emmy-Noether-Research groupe – Innate Lymphoid Cells in Renal Inflammation
Senior Physician
Medical Specialist in Internal Medicine and Nephrology
III. Department of Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 54167
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine at the University of Göttingen
  • M.D. thesis at the European Neuroscience Institute Göttingen
  • Assistant Physician at the III. Medizinische Klinik, UKE
  • DFG Research Fellowship at the MRC National Institute for Medical Research, London
  • Clinical Specialization in Internal Medicine and Nephrology
  • Junior Research Group Leader funded by the DFG Emmy-Noether-Programm (Topic: “Innate Lymphoid Cells in Renal Inflammation”)
  • Habilitation and “Venia legend” for Internal Medicine and Nephroloy
  • Consultant Physician at the III. Medizinische Klinik, UKE
Awards
  • Award of the Walter-Hörl-Fellowship of the German Kidney Foundation (2013)
  • Hans-U.-Zollinger-Research-Award of the German Society of Nephrology (2018)
Publications during the first funding period of the SFB 1192

  • Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

    Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

  • T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus. 

    Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JEEur J Immunol. 2018 Aug

  • Innate lymphoid cells in autoimmunity and chronic inflammatory diseases. 

    Xiong T, Turner JESemin Immunopathol. 2018 Jul

  • Innate Lymphoid Cells – Key players in tissue-specific immunity. 

    Turner JE, Gasteiger GSemin Immunopathol. 2018 Jul

  • IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation. 

    Krohn S, Nies JF, Kapffer S, Schmidt T, Riedel JH, Kaffke A, Peters A, Borchers A, Steinmetz OM, Krebs CF, Turner JE, Brix SR, Paust HJ, Stahl RAK, Panzer UJ Am Soc Nephrol. 2018 Apr

  • Tissue-Resident Lymphocytes in the Kidney. 

    Turner JE, Becker M, Mittrücker HW, Panzer UJ Am Soc Nephrol. 2018 Feb

  • Natural killers: the bad guys in fibrosis? 

    Turner JEKidney Int. 2017 Jul

  • IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

    Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

  • Plasticity of Th17 Cells in Autoimmune Kidney Diseases. 

    Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer UJ Immunol. 2016 Jul

  • IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

    Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U J Am Soc Nephrol. 2016 Dec

  • Immune Mechanisms in Arterial Hypertension

    Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

  • Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

    Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

Further selected Publications
  • IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation.
    Turner JE, Morrison PJ, Wilhelm C, Wilson M, Ahlfors H, Renauld JC, Panzer U, Helmby H, Stockinger B
    J Exp Med. 2013

  • Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
    Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B
    Nat Immunol. 2013

  • IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection.
    Turner JE, Stockinger B, Helmby H
    PLoS Pathog. 2013

  • IL-17A production by renal gd T cells promotes kidney injury in crescentic GN.
    Turner JE, Krebs C, Tittel AP, Paust HJ, Meyer-Schwesinger C, Bennstein SB, Steinmetz OM, Prinz I, Magnus T, Korn T, Stahl RA, Kurts C, Panzer U
    J Am Soc Nephrol. 2012

  • CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis.
    Turner JE, Paust HJ, Steinmetz OM, Peters A, Riedel JH, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrucker HW, Tiegs G, Stahl RA, Panzer U
    J Am Soc Nephrol. 2010

  • The many lives of IL-9: a question of survival?
    Wilhelm C, Turner JE, Van Snick J, Stockinger B
    Nat Immunol. 2012

  • The Th17 immune response in renal inflammation.
    Turner JE, Paust HJ, Steinmetz OM, Panzer U
    Kidney Int. 2010

Prof. Dr. rer. nat. Peter Zipfel

Projek Leader B6
Leibniz Institute for Natural Product Research and Infection Biology
Hans Knöll Institute (HKI), Jena
Phone: +49 3641 532-1301
E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Biology, Cell Biology and Biochemistry at the University of Bremen
  • Ph.D. thesis at the University of Bremen
  • Postdoc at the Laboratory of Immunoregulation at the National Institute of Health, Bethesda, Maryland, USA
  • Visiting Associate at the Laboratory of Immunoregulation at the National Institute of Health, Bethesda, Maryland, USA
  • Head of a research group at the Bernhard Nocht Institute for Tropical Medicine, Hamburg
  • Adjunct Professor at the University of Hamburg
  • Head of Department of Infection Biology at the Leibniz Institute for Natural Product Research and Infection Biology, HKI, Jena
  • Universtiy Professor for Infection Biology at the Friedrich Schiller University Jena
  • Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology, HKI, Jena
  • Spokesperson for the International Leibniz Research School for Microbial and Biomolecular Interactions
  • President of the European Complement Network (2011- 2014)
  • Board member of the International Complement Society (ICS)
  • Chairman of the Beutenberg Campus e.V, , Jena
Awards
  • Thuringian Research Award (2004)
  • Heinz Spitzbart Award of the European Society for Infectious Diseases in Obstetrics and Gynaecology (2007)
  • EFIS Lecture Award of the European Federation of Immunological Societies (2008)
  • Research Award of the German Society of Hygiene and Microbiology (2009)
  • Galenus-von Pergamon-Preis in Basic Science (2014)
Publications during the first funding period of the SFB 1192

  • Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

    Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel & Christine SkerkaNat Commun. 2019 Jul

  • C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.

    Zhao F, Afonso S, Lindner S, Hartmann A, Löschmann I, Nilsson B, Ekdahl KN, Weber LT, Habbig S, Schalk G, Kirschfink M, Zipfel PF, Skerka C.Front Immunol. 2019 May

  • ApoE attenuates unresolvable inflammation by complex formation with activated C1q.

    Yin C, Ackermann S, Ma Z, Mohanta SK, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Markus Hildner M, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Habenicht L, Binder CJ, Weber C*, Zipfel PF *, Skerka C*, Habenicht AJR* Nat Med. 2019 Mar *equal contribution

  • C3 Glomerulopathy-Understanding a Rare Complement-Driven Renal Disease.

    Smith RJH, Appel G, Blom AM, Cook HT, D’Agati V, Fakhouri F, Véronique Fremeaux-Bacchi V, Józsi M, Kavanagh D, Lambris J, Noris M, Pickering MC, Remuzzi G, Santiago Rodriguez de Córdoba S, Sethi S, Van der Vlag J, Zipfel PF, Nester CMNat Rev Nephrol. 2019 Mar

  • The Case | A 78-year-old woman with acute kidney injury and hemolytic anemia.

    Zecher D, Banas B, Büttner-Herold M, Kirschfink M, Zipfel PF Kidney Int. 2019 Feb

  • Bevacizumab-associated glomerular microangiopathy.

    Person F, Rinschen M, Brix S, Wulf S, Noriega M, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz O, Reinhard L, Hoxha E, Zipfel P, Bräsen J, Wiech TMod Pathol. 2018 Dec

  • FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

    Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PFJ Immunol. 2018 Apr

  • FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. 

    Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka CJ Immunol. 2016 Jul

  • The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

    Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

Further selected Publications
  • C1q-ApoE complexes control unresolvable inflammation.
    Yin C, Ackermann S, Ma Z, Mohanta SK, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Markus Hildner M, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Habenicht L, Binder CJ, Weber C*, Zipfel PF *, Skerka C*, Habenicht AJR*
    Nat Med. 2019 Mar;25(3):496-506 *equal contribution
  • CFHR5-Hybrid proteins anchor properdin and activate complement at self-surfaces.
    Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF
    J Am Soc Nephrol, 27: 1413-1425
  • Complement factor H–related hybrid protein deregulates complement in dense deposit disease
    Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Büttner M, Goodship T, Hugo C, Skerka C, Zipfel PF
    J Clin Invest 124:145–155
  • Combined C3b and Factor B Autoantibodies and MPGN Type II.
    Chen C, Müller D, Rudolph B, Hartmann A, Kuwertz-Bröking E, Wu K, Kirschfink M, Skerka C, Zipfel PF
    N Engl J Med 365:2340-2342
  • Complement Factor H binds malondialdehyde-epitopes and protects from oxidative stress.
    Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HPN , Charbel Issa P, Cano M, Brandstätter H, Tsimikas S , Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ
    Nature 478:76-81

Prof. Dr. med. Thorsten Wiech

Project Leader B6
Leading Consultant (Oberarzt)
Medical Specialist in Pathology
Institute for Pathology, UKE Hamburg

Phone  +49 (0) 40 7410 - 59393
Mobil  +49 (0) 152 22816886
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career

1995 – 2002    Study of Medicine at the University Hamburg
2000 – 2004    M.D. thesis at the Medizinische Kernklinik, UKE
2001 - 2011    Resident (Assistenzarzt) at the Institute of Pathology Freiburg
2008 - 2009    Training in Nephropathology, Institute of Pathology Basel
2010                Specialization in Pathology
2012                Habilitation in Pathology at the University Freiburg
Since 2012      Consultant (Oberarzt) at the Institute of Pathology, UKE
Since 2012      W2 Professor at the Institute of Pathology, UKE

 

Awards
  • Michael J. Mihatsch & Dusan Ferluga Award of the European Society of Pathology
Publications during the first funding period of the SFB 1192

  • Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy.

    Mahmud M, Pinnschmidt HO, Reinhard L, Harendza S, Wiech T, Stahl RAK, Hoxha E PLoS One. 2019 Sep

  • Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

    Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel & Christine SkerkaNat Commun. 2019 Jul

  • Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T-cell responses.

    Breda PC, Wiech T, Meyer-Schwesinger C, Grahammer F, Huber TB, Panzer U, Tiegs G, Neumann K.Am J Physiol Renal Physiol. 2019 Apr

  • Diagnostic role of renal biopsy in PLA2R1-antibody-positive patients with nephrotic syndrome.

    Wiech T, Stahl RAK, Hoxha E Mod Pathol. 2019 Sep

  • Bevacizumab-associated glomerular microangiopathy.

    Person F, Rinschen M, Brix S, Wulf S, Noriega M, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz O, Reinhard L, Hoxha E, Zipfel P, Bräsen J, Wiech TMod Pathol. 2018 Dec

  • Development and validation of a renal risk score in ANCA-associated glomerulonephritis

    Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

  • Potential role for urine PCR in the diagnosis of Whipple's disease.

    Moter A, Janneck M, Wolters M, Iking-Konert C, Wiessner A, Loddenkemper C, Hartleben B, Lütgehetmann M, Schmidt J, Langbehn U, Janssen S, Geelhaar-Karsch A, Schneider T, Moos V, Rohde H, Kikhney J, Wiech T.Clin Infect Dis. 2018 Oct

  • Lupusnephritis

    Melderis S, Wiech T, Iking-Konert C, Steinmetz OZ Rheumatol. 2018 Sep

  • The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

    Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

  • Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

    Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

  • FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

    Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PFJ Immunol. 2018 Apr

  • Immunohistochemical and serological characterization of membranous nephropathy in children and adolescents

    Dettmar A, Wiech T, Kemper M, Soave A, Rink M, Oh J, Stahl R, Hoxha E Pediatr Nephrol. 2018 Mar

  • Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

    Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

  • Membranous nephropathy-one morphologic pattern with different diseases

    Hoxha E, von Haxthausen F, Wiech T, Stahl RPflugers Arch. 2017 Aug

  • THSD7A expression in human cancer

    Stahl P, Hoxha E, Wiech T, Schröder C, Simon R, Stahl R Genes Chromosomes Cancer. 2017 Apr

  • An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

    Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R J Am Soc Nephrol. 2017 Feb

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

  • A Mechanism for Cancer-Associated Membranous Nephropathy. 

    Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

Further selected Publications
  • CXCR3+ regulatory T cells control TH1 responses in crescentic GN. 
    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H-W, Steinmetz OM, Stahl RA, Panzer U.
    J Am Soc Nephrol. 2016 Jul;27(7):1933-42.
  • FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. 
    Zhou W, Otto EA, Cluckey A, Airik R, Hurd TW, Chaki M, Diaz K, Lach FP, Bennett GR, Gee HY, Ghosh AK, Natarajan S, Thongthip S, Veturi U, Allen SJ, Janssen S, Ramaswami G, Dixon J, Burkhalter F, Spoendlin M, Moch H, Mihatsch MJ, Verine J, Reade R, Soliman H, Godin M, Kiss D, Monga G, Mazzucco G, Amann K, Artunc F, Newland RC, Wiech T, Zschiedrich S, Huber TB, Friedl A, Slaats GG, Joles JA, Goldschmeding R, Washburn J, Giles RH, Levy S, Smogorzewska A, Hildebrandt F. 
    Nat Genet. 2012 Jul 8;44(8):910-5.

  • Histopathological patterns of nephrocalcinosis: a phosphate type can be distinguished from a calcium type. 
    Wiech T, Hopfer H, Gaspert A, Banyai-Falger S, Hausberg M, Schröder J, Werner M, Mihatsch MJ. 
    Nephrol Dial Transplant. 2012 Mar;27(3):1122-31.

Dr. rer. nat. Tobias Fuchs

Project Leader A7

Institute of Clinical Chemistry and Laboratory Medicine, UKE Hamburg

Phone  +49 (0) 40 7410 - 51908
Fax  +49 (0) 40 7410 - 54971
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Biology at the University of Würzburg
  • Ph.D. thesis at the Max Planck Institute for Infection Biology Berlin
  • DFG Fellowship at Immune Disease Institute and Harvard Medical School
  • Postdoctoral Fellowship at Immune Disease Institute and Harvard Medical School
  • Instructor at Immune Disease Institute and Harvard Medical School
  • Group Leader at the University Medical Center Hamburg-Eppendorf
  • Marie Curie Fellowship at the University Medical Center Hamburg-Eppendorf
Awards
  • Young Talent Award of the Society for Thrombosis and Hemostasis Research
  • Alexander Schmidt Award of the Society for Thrombosis and Hemostasis Research
Publications during the first funding period of the SFB 1192

  • Host DNases prevent vascular occlusion by neutrophil extracellular traps.

    Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TAScience. 2017 Dec

Further selected Publications
  • Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism.
    Jiménez-Alcázar M*, Limacher A*, Panda R, Méan M, Bitterling J, Peine S, Renné T, Beer JH, Aujesky D, Lämmle B, Fuchs TA.
    PLoS One. 2018

  • Therapeutic targeting of extracellular DNA improves the outcome of intestinal infarction in neonatal rats.
    Boettcher M, Eschenburg G, Mietzsch S, Jiménez-Alcázar M, Klinke M, Vincent D, Tiemann B, Bergholz R, Reinshagen K, Fuchs TA.
    Sci Rep. 2017

  • Neutrophil extracellular traps contain selected antigens of anti-neutrophil cytoplasmic antibodies.
    Panda R, Krieger T, Hopf L, Renné T, Haag F, Röber N, Condrad K, Csernok E, Fuchs TA.
    Front Immunol. 2017

  • Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies
    Jiménez-Alcázar M, Napirei M, Panda R, Köhler EC, Kremer-Hovinga JA, Mannherz HG, Peine S, Renné T, Lämmle B, Fuchs TA.
    J Thromb Haemost. 2015

  • Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic Cicroangiopathies
    Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lämmle B.
    Blood. 2012

  • Histones induce rapid and profound thrombocytopenia in mice
    Fuchs TA, Bhandari AA, Wagner DD.
    Blood. 2011

  • Extracellular DNA traps promote thrombosis.
    Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD Jr, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD.
    Proc Natl Acad Sci U S A. 2010

  • Novel cell death program leads to neutrophil extracellular traps
    Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, Weinrauch Y, Brinkmann V,
    Zychlinsky A.
    J Cell Biol. 2007

Prof. Dr. med. Ulrich Wenzel

Project Leader B7

Senior physician
Medical specialist in Internal Medicine and Nephrology
III. Department of Medicine, UKE Hamburg

Telefon +49 (0) 40 7410 - 0
E-Mail This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine at the University Berlin
  • M.D. thesis at the Klinikum Steglitz, University of Berlin
  • Assistant Physician at the Medizinische Klinik at the University of Frankfurt and later on at the III. Medizinische Klinik at the UKE
  • DFG Fellowship Postdoc Health Science Center at San Antonio, USA
  • Clinical Specialization in Internal Medicine and Nephrology
  • Habilitation in Internal Medicine, University Hamburg
  • Consultant (Oberarzt), III. Medizinische Klinik, UKE
  • Professor at the III. Medizinische Klinik, UKE
  • Acting director of Medizinische Klinik I, Hospital Herne, University of Bochum (2010-2011)
Awards
  • Franz-Gross-Wissenschaftspreis Deutsche Hochdruckliga
Publications during the first funding period of the SFB 1192

  • Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice.

    Rosendahl A, Kabiri R, Bode M, Cai A, Klinge S, Ehmke H, Mittrücker HW, Wenzel UOBr J Pharmacol. 2018 Sep

  • The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

    Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

  • Salt, inflammation, IL-17 and hypertension.

    Wenzel UO, Bode M, Kurts C, Ehmke H.Br J Pharmacol. 2018 May

  • Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

    Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

  • A pathogenic role of complement in arterial hypertension and hypertensive end organ damage.

    Wenzel UO, Bode M, Köhl J, Ehmke HAm J Physiol Heart Circ Physiol. 2017 Mar

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

  • The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

    Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

  • A Mechanism for Cancer-Associated Membranous Nephropathy. 

    Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

  • Immune Mechanisms in Arterial Hypertension

    Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

Further selected Publications
  • Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate and angiotensin II-induced hypertension.
    Krebs CF, Lange S, Niemann G, Rosendahl A, Lehners A, Meyer-Schwesinger C, Stahl RA, Benndorf RA, Velden J, Paust HJ, Panzer U, Ehmke H, Wenzel UO.
    Hypertension. 2014

  • AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.
    Fraune C, Lange S, Krebs C, Hölzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garrelds IM, Danser AH, Frenay AR, van Goor H, Jankowski V, Stahl R, Nguyen G, Wenzel UO.
    Am J Physiol Renal Physiol. 2012

  • Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
    Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Nickenig G, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S.
    Nat Med. 2010

  • Rapid development of severe endorgan damage in C57black mice by combining DOCA salt and angiotensin II.
    Kirchhoff F, Krebs C, Abdulhag UN, Meyer-Schwesinger C, Maas R, Helmchen U, Hilgers K, Wolf G, Stahl RAK, Wenzel U.
    Kidney Int. 2008

Prof. Dr. med. Heimo Ehmke

Project Leader B7

Institute director of the Institute of Cellular and Integrative Physiology
Tel: +49 (0) 40 7410 – 52182
Telefax: +49 (0) 40 7410 – 59299
E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine at the University of Heidelberg
  • MD thesis at the Institute of Pathology, University of Heidelberg
  • Postdoc at the Institute of Physiology I, Department of Biophysics of the Circulation, University of Heidelberg
  • Habilitation and Venia Legendi for Physiology, University of Heidelberg
  • Visiting Scientist at the Max-Planck-Institute for Medical Research Heidelberg, Department of Cell Physiology
  • Junior Research Group Leader (Physiology), University of Heidelberg
  • Visiting Scientist at the EMBL, Heidelberg
  • Professor and Chair of Medicine (Physiology), UKE
  • Vice Speaker of the Forschergruppe 604
  • Scientific Director of the Center for Experimental Medicine, UKE
  • Speaker of the Translational Research Group, DZHK
Publications during the first funding period of the SFB 1192

  • Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice.

    Rosendahl A, Kabiri R, Bode M, Cai A, Klinge S, Ehmke H, Mittrücker HW, Wenzel UOBr J Pharmacol. 2018 Sep

  • The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

    Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

  • Salt, inflammation, IL-17 and hypertension.

    Wenzel UO, Bode M, Kurts C, Ehmke H.Br J Pharmacol. 2018 May

  • A pathogenic role of complement in arterial hypertension and hypertensive end organ damage.

    Wenzel UO, Bode M, Köhl J, Ehmke HAm J Physiol Heart Circ Physiol. 2017 Mar

  • The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

    Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

  • Immune Mechanisms in Arterial Hypertension

    Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

Further selected Publications
  • The mechanotransduction of blood pressure.
    Ehmke H
    Science. 2018

  • Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
    Heinze C, Seniuk A, Sokolov MV, Huebner AK, Klementowicz AE, Szijártó IA, Schleifenbaum J, Vitzthum H, Gollasch M, Ehmke H, Schroeder BC, Hübner CA.
    J Clin Invest. 2014

  • Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice.
    Vitzthum H, Seniuk A, Schulte LH, Müller ML, Hetz H, Ehmke H.
    J Physiol. 2014

  • Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate and angiotensin II-induced hypertension.
    Krebs CF, Lange S, Niemann G, Rosendahl A, Lehners A, Meyer-Schwesinger C, Stahl RA, Benndorf RA, Velden J, Paust HJ, Panzer U, Ehmke H, Wenzel UO.
    Hypertension. 2014

  • Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis.
    Gröger N, Vitzthum H, Fröhlich H, Krüger M, Ehmke H, Braun T, Boettger T (2012).
    Hum Mol Genet. 2012

  • Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
    Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Nickenig G, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S.
    Nat Med. 2010

  • Control of heart rate by cAMP sensitivity of HCN channels.
    Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.
    Proc Natl Acad Sci U S A. 2009

  • Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.
    Zimmermann WH, Melnychenko I, Wasmeier G, Didié M, Naito H, Nixdorff U, Hess A, Budinsky L, Brune K, Michaelis B, Dhein S, Schwoerer A, Ehmke H, Eschenhagen T.
    Nat Med. 2006

Prof. Dr. med. Christian Kurts

Project Leader A8

Medical Specialist for Internal medicine and Nephrology
Institute of Experimental Immunology University Bonn
Telefone: +49-(0) 228-287-11050,
Telefax: +49-(0) 228-287-11052
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine and physics at the University of Göttingen
  • M.D. thesis, Dept. of Immunology at the University of Göttingen,
  • Medical Officer and Research Fellow at the Department of Nephrology, Medical School Hannover (MHH)
  • Postdoctoral Research Fellow at the The Walter and Eliza Hall Institute for Medical Research (WEHI), Melbourne, Australia
  • Habilitation (lectureship) for Experimental Nephrology
  • Board certification for Internal Medicine
  • Research group leader, Dept. of Nephrology and Clinical Immunology, RWTH Aachen
  • Heisenberg fellowship of the DFG
  • Full C3 Professor of Molecular Immunology University of Bonn
  • Director Institute of Experimental Immunology, University of Bonn
  • Co-speaker SFB TR57 “Organ-Fibrosis”, organizing the Bonn site
  • Co-speaker SFB 704
  • Elected member German National Academy of Sciences Leopoldina
  • Speaker international graduate school GRK 2168 Bo&MeRanG
    (Bonn & Melbourne Research and Graduate training Group)
  • Board member DFG Excellence Cluster “ImmunoSensation2”, Bonn
Awards
  • Sir Hans Krebs Preis for Basic Medical Research (1999)
  • Hans-U.-Zollinger-Award of the German Society for Nephrology (2010)
  • Gottfried-Wilhelm-Leibniz-Prize of the DFG (2012)
Publications during the first funding period of the SFB 1192

  • Protecting the kidney against autoimmunity and inflammation.

    Christian Kurts, Catherine Meyer-SchwesingerNat Rev Nephrol. 2018 Dec

  • The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

    Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

  • Salt, inflammation, IL-17 and hypertension.

    Wenzel UO, Bode M, Kurts C, Ehmke H.Br J Pharmacol. 2018 May

  • Pro-longed IKKβ inhibition improves ongoing CTL antitumor responses by incapacitating regulatory T cells.

    Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges JF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine AK, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.Cell Rep. 2017 Oct

  • Fully automated evaluation of total glomerular num-ber and capillary tuft size in murine nephritic kidneys using lightsheet microscopy.

    Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Matthias GunzerJ Am Soc Nephrol. 2017 Feb

  • Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Ag-gravates the Progression of crescentic glomerulonephritis.

    Gotot J, Piotrowski E, Otte MS, Tittel AP, Guo L, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss FJ Am Soc Nephrol. 2016 Jul

  • CXCR3+ regulatory T cells control Th1 responses in crescentic GN.

    Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U.J Am Soc Nephrol. 2016 Jul

  • A NLRP3-specific inflammasome inhibitor potently attenuates crystal-induced kidney fibrosis in vivo.

    Ludwig-Portugall I,*, Bartok E,* Dhana E, Evers BDG, Primiano MJ, Hall PJ, Franklin BS, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.Kidney Int 2016

  • The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

    Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

  • CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

    Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts CJ Am Soc Nephrol. 2016 Nov

  • Immune Mechanisms in Arterial Hypertension

    Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

Further selected Publications
  • Assessing core competences of medical students with a test for flight school applicants
    Harendza S, Soll H, Prediger S, Kadmon M, Berberat PO, Oubaid V
    BMC Med Educ. 2019

  • Perceived strain of undergraduate medical students during a simulated first day of residency.
    Fürstenberg S, Prediger S, Kadmon M, Berberat PO, Harendza S
    BMC Med Educ. 2018

  • Verbal and non-verbal communication skills including empathy during history taking of undergraduate medical students.
    Vogel D, Meyer M, Harendza S
    BMC Med Educ. 2018

  • Implementation of a Clinical Reasoning Course in the Internal Medicine trimester of the final year of undergraduate medical training and its effect on students’ case presentation and differential diagnostic skills.
    Harendza S, Krenz I, Klinge A, Wendt U, Janneck M
    GMS J Med Educ. 2017

  • Is perfect good? – Dimensions of perfectionism in newly admitted medical students.
    Seeliger H, Harendza S
    BMC Med Educ. 2017

  • Competencies for first year residents – physicians’ views form medical schools with different undergraduate curricula.
    Fürstenberg S, Schick K, Deppermann J, Prediger S, Berberat PO, Kadmon M, Harendza S (2017).
    BMC Med Educ. 2017

  • Influence of motivation, self-efficacy and situational factors on the teaching quality of clinical educators.
    Dybowski C, Sehner S, Harendza S (2017).
    BMC Med Educ. 2017

  • Analysis of educational research at a medical faculty in Germany and suggestions for strategic development – a case study.
    Prediger S, Harendza S (2016).
    GMS J Med Educ. 2016

  • Psychometric properties of the newly developed Physician Teaching Self-Efficacy Questionnaire (PTSQ).
    Dybowski C, Kriston L, Harendza S (2016).
    BMC Med Educ. 2016

  • Translating medical documents into plain language enhances communication skills in medical students – A pilot study.
    Bittner A, Jonietz A, Bittner J, Beickert L, Harendza S (2015)
    Patient Educ Couns. 2015

Prof. Dr. med. Sigrid Harendza, MME (Bern)

Integrated Graduate School
Medical Specialist in Internal Medicine and Nephrology
Consultant (Oberarzt)
III. Department of Medicine, UKE Hamburg

Telefon  +49 (0) 40 7410 - 54167
Telefax  +49 (0) 40 7410 - 40218
E-Mail  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career
  • Study of Medicine at the University of Frankfurt/Main
  • M.D. thesis at the University of Frankfurt/Main
  • Internship at the Dept. of Nephrology at the University Hospital Frankfurt/Main
  • DFG Postdoctoral Scholarship at the Dept. of Nephrology, VAMC, University of California, San Francisco, USA
  • Residency at the III. Medizinische Klinik, UKE
  • Master of Medical Education at the University Bern, Switzerland
  • Clinical Specialization for Internal Medicine and for Nephrology
  • Habilitation in Internal Medicine at the University of Hamburg
  • Consultant (Oberarzt) at the III. Medizinische Klinik, UKE
  • Vice-Dean of Education, Medical Faculty, University Hamburg (2006-2007)
  • University Professor (W3) for Internal Medicine/Educational Research at the III. Medizinische Klinik, UKE
Awards
  • 1992 Carl Oelemann Award (best doctoral thesis in the state of Hesse)
  • 2000 Janssen Cilag Award (best basic research project in nephrology)
  • 2005 Poster Award of the German Society of Internal Medicine
  • 2006 Ars legendi-Award by the Stifterverband for innovation in university teaching
  • 2013 Best Paper Award, III. Research in Medical Education Conference, Berlin
  • 2015 Fellowship by the Stifterverband for innovation in university teaching
  • 2018 Fellowship by the Teaching Laboratory of the University College of the University of Hamburg
  • 2019 Hamburg Teaching Award
Selected Publications
  • Assessing core competences of medical students with a test for flight school applicants 
    Harendza S, Soll H, Prediger S, Kadmon M, Berberat PO, Oubaid V
    BMC Med Educ 2019
  • Perceived strain of undergraduate medical students during a simulated first day of residency.
    Fürstenberg S, Prediger S, Kadmon M, Berberat PO, Harendza S
    BMC Med Educ 2018
  • Verbal and non-verbal communication skills including empathy during history taking of undergraduate medical students.
    Vogel D, Meyer M, Harendza S
    BMC Med Educ 2018
  • Implementation of a Clinical Reasoning Course in the Internal Medicine trimester of the final year of undergraduate medical training and its effect on students’ case presentation and differential diagnostic skills.
    Harendza S, Krenz I, Klinge A, Wendt U, Janneck M
    GMS J Med Educ 2017
  • Is perfect good? – Dimensions of perfectionism in newly admitted medical students.
    Seeliger H, Harendza S
    BMC Med Educ 2017
  • Competencies for first year residents – physicians’ views form medical schools with different undergraduate curricula.
    Fürstenberg S, Schick K, Deppermann J, Prediger S, Berberat PO, Kadmon M, Harendza S
    BMC Med Educ 2017
  • Influence of motivation, self-efficacy and situational factors on the teaching quality of clinical educators.
    Dybowski C, Sehner S, Harendza S
    BMC Med Educ 2017
  • Analysis of educational research at a medical faculty in Germany and suggestions for strategic development – a case study.
    Prediger S, Harendza S
    GMS J Med Educ 2016
  • Psychometric properties of the newly developed Physician Teaching Self-Efficacy Questionnaire (PTSQ).
    Dybowski C, Kriston L, Harendza S
    BMC Med Educ 2016
  • Translating medical documents into plain language enhances communication skills in medical students – A pilot study.
    Bittner A, Jonietz A, Bittner J, Beickert L, Harendza S
    Patient Educ Couns 2015

SFB 1192

Project Leader Associated Working Groups

Prof. Dr. Nicola Gagliani

General, Visceral and Thoracic Surgery Department
UKE Hamburg
SFB 1192 associated project

Phone: +49 (0) 40 7410 - 50852
E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific career

• Bachelor’s degree in Biotechnology, University of Milano-Bicocca (IT)
• Master’s degree in Medical Biotechnology, University of Milano-Bicocca (IT)
• Bachelor’s Thesis, Ospedale San Raffaele (IT)
• Master’s Thesis, Beth Israel Deaconess Medical Center, Harvard Medical
School (USA)
• Ph.D. in Molecular Medicine, Università Vita-Salute San Raffaele (IT)
• International lab experience as Ph.D. student, Yale School of Medicine (USA)
• Postdoctoral fellow, Yale School of Medicine, Department of Immunobiology (USA)
• Assistant Professor (25%) of Molecular Medicine, Karolinska Institute, Stockholm (SE)
• W3 Professor of Gastrointestinal Carcinogenesis, University Medical Center Hamburg-Eppendorf (DE)

Publications during the first funding period of the SFB 1192

  • Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

    Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson J, Antonson P, Roncarolo M, Villablanca E, Gagliani N, Huber SNat Commun. 2018 Dec

  • IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.

    Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S.J Immunol. 2017 Feb

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. 

    Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U.Immunity. 2016 Nov

Further selected Publications
  • TH17 cell plasticity: The role of dendritic cells and molecular mechanisms.
    Agalioti T, Villablanca EJ, Huber S, Gagliani N.
    J Autoimmun. 2018

  • Intestinal IFN-γ-producing Tr1-cells co-express CCR5 and PD-1, and down-regulate IL-10 in the inflamed gut of IBD patients.
    Alfen JS*, Larghi P*, Facciotti F*, Gagliani N*, Bosotti R, Paroni M, Maglie S, Gruarin P, Vasco CM, Ranzani V, Frusteri C, Iseppon A, Moro M, Crosti MC, Gatti S, Pagani M, Caprioli F, Abrignani S, Flavell RA, Geginat J.
    J Allergy Clin Immunol. 2018

  • Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.
    Bosurgi L, Cao Y G, Cabeza-Cabrerizo M, Tucci A, Hughes L D, Kong Y, Weinstein J S, Licona-Limon P, Schmid E T, Pelorosso F, Gagliani N, Craft J E, Flavell R A, Ghosh S, Rothlin C V.
    Science. 2017

  • A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.
    Pelczar, P., M. Witkowski, L. G. Perez, J. Kempski, A. G. Hammel, L. Brockmann, D. Kleinschmidt, S. Wende, C. Haueis, T. Bedke, M. Witkowski, S. Krasemann, S. Steurer, C. J. Booth, P. Busch, A. Konig, U. Rauch, D. Benten, J. R. Izbicki, T. Rosch, A. W. Lohse, T. Strowig, N. Gagliani*, R. A. Flavell*, and S. Huber*. *contributed equally
    Science. 2016

  • Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
    Gagliani, N., M. C. Amezcua Vesely, A. Iseppon, L. Brockmann, H. Xu, N. W. Palm, M. R. de Zoete, P. Licona-Limon, R. S. Paiva, T. Ching, C. Weaver, X. Zi, X. Pan, R. Fan, L. X. Garmire, M. J. Cotton, Y. Drier, B. Bernstein, J. Geginat, B. Stockinger, E. Esplugues, S. Huber*, and R. A. Flavell*. *contributed equally
    Nature. 2015

  • The Fire Within: Microbes inflame tumor.
    Gagliani N*, Bo H*, Huber S*, Elinav E*, Flavell RA.
    Cell. 2014

  • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.
    Gagliani N*, Magnani CF*, Huber S*, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A, Trentini F, Di Serio C, Bacchetta R, Andreani M, Brockmann L, Gregori S, Flavell RA, Roncarolo MG. *contributed equally
    Nat Med. 2013

  • Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
    Huber S*, Gagliani N*, Esplugues E*, O'Connor WJr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. *contributed equally
    Immunity. 2011

Prof. Dr. med. Tobias B. Huber

Chairman and Director
III. Department of Medicine, UKE Hamburg
SFB 1192 associated project (2017-2019)

Phone: +49 (0) 40 7410 - 53908
Fax: +49 (0) 40 7410 - 45186
E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Scientific career
  • Study of Medicine, Universities of Freiburg, Vienna, South Florida (USA)
  • MD in Physiology, University Medical Center Freiburg, summa cum laude
  • Residency and Fellow in Medicine, University Medical Center Freiburg
  • Emmy Noether Program – Phase I/ Postdoctoral Fellow, Immunology & Pathology, Washington University St. Louis, USA
  • USMLE US-American Full Medical Licence
    Emmy Noether Program – Phase II/ Group leader, University Freiburg
  • Habilitation, University Freiburg
    Board Exam in Internal Medicine and Nephrology
  • Attending Physician, Department of Medicine IV, University Freiburg
  • Associated Member of the BIOSS Excellence Cluster, Freiburg
  • Heisenberg Fellowship, University Freiburg
  • W3-Heisenbergprofessorship, University Medical Center Freiburg
  • Deputy Chair, Department of Medicine IV, University Freiburg
  • Co-Chair Else Kröner-Fresenius Kolleg “NAKSYS”, University Medical Center Freiburg
  • Director and Chairman of the III. Department of Medicine, UKE, Hamburg
  • Chair Else Kröner-Fresenius Kolleg “iPRIME”, UKE
Awards

DFG programs awarded:

  • Emmy Noether Program – Phase I/ Postdoctoral Fellow, Immunology & Pathology, Washington University St. Louis, USA (2003-2006)
  • Emmy Noether Program – Phase II/ Group leader, University Medical Center Freiburg (2006-2011)
  • Heisenberg Fellow, University Medical Center Freiburg (2011-2013)
  • W3-Heisenbergprofessorship, University Medical Center Freiburg (2013-2017)

 

Other:

  • Young Nephrologist Award of the German Renal Society (2002)
  • Carl Ludwig Award of the German Renal Society (2004)
  • PI of the SGBM Graduate School, Freiburg (since 2006)
  • Member of the German and American Renal Society (since 2007)
  • Associated Member of the BIOSS Excellence Cluster, Freiburg (since 2008)
  • Hans U. Zollinger Research Award of German Renal Society (2009)
  • Franz-Volhard Award of the German Renal Society (2010)
  • Young Investigator Award of the American Society of Nephrology and the American Heart Association (2012)
  • Elected Member of the American Society of Clinical Investigation (2014)
  • Recipient of the European Research Council Grant(2014)
  • Co-Chair Else Kröner-Fresenius Kolleg “NAKSYS”, University Medical Center Freiburg (2017)
  • Chair Else Kröner-Fresenius Kolleg “iPRIME”, UKE (2018)
Publications during the first funding period of the SFB 1192
  • DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation
    Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles V, Rahman R, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek M, Romano T, Moritz K, Boerries M, Busch H, Bonn S, Little M, Bechtel-Walz W, Huber T
    J AM SOC NEPHROL. 2019;30(1):63-78.

  • ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier. 
    Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold HH, Dengjel J, Rogg M, Huber TB. 
    Dev Cell. 2018 Dec 17;47(6):741-757

  • A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. 
    Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. 
    Cell Rep. 2018 May 22;23(8):2495-2508

  • Development and validation of a renal risk score in ANCA-associated glomerulonephritis
    Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech T
    Kidney Int. 2018 Dec;94(6):1177-1188.

  • The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension
    Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel U
    Am J Physiol Renal Physiol. 2018 Sep 12.

  • Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis
    Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech T
    Histopathology. 2018 Jun;72(7):1093-1101.
Further selected Publications
  • DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.
    Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles V, Rahman R, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek M, Romano T, Moritz K, Boerries M, Busch H, Bonn S, Little M, Bechtel-Walz W, Huber T
    J Am Soc Nephrol.. 2019 Jan
  • A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.
    Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. 
    Cell Rep. 2018 May
  • ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier.
    Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold HH, Dengjel J, Rogg M, Huber TB. 
    Dev Cell. 2018 Dec
  • The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.
    Schell C, Rogg M, Suhm M, Helmstadter M, Sellung D, Yasuda-Yamahara M, Kretz O, Kuttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, and Huber TB.
    Proc Natl Acad Sci U S A. 2017

  • mTORC2 critically regulates renal potassium handling.
    Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, and Huber TB.
    J Clin Invest. 2016

  • Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.
    Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, and Pearce EL.
    Cell. 2016

  • Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
    Godel M, Grahammer F, and Huber TB.
    N Engl J Med. 2015

  • Calciphylaxis.
    Zhou Q, Neubauer J, Kern JS, Grotz W, Walz G, and Huber TB.
    Lancet. 2014

  • mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.
    Grahammer F, Haenisch N, Steinhardt F, Sandner L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, and Huber TB.
    Proc Natl Acad Sci U S A. 2014

  • Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.
    Godel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S, Debreczeni-Mor A, Lindenmeyer MT, Rastaldi MP, Hartleben G, Wiech T, Fornoni A, Nelson RG, Kretzler M, Wanke R, Pavenstadt H, Kerjaschki D, Cohen CD, Hall MN, Ruegg MA, Inoki K, Walz G, and Huber TB.
    J Clin Invest. 2011

  • Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
    Hartleben B, Godel M, Meyer-Schwesinger C, Liu S, Ulrich T, Kobler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstadt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, and Huber TB.
    J Clin Invest. 2010

III. Medizinische Klinik und Poliklinik
Universitätsklinikum Hamburg-Eppendorf

Martinistrasse 52
20246 Hamburg, Germany
Tel:   +49-40-7410-51557
Fax:  +49-40-7410-59036
This email address is being protected from spambots. You need JavaScript enabled to view it.