Publications
An integrated organoid omics map extends modeling potential of kidney disease.
Lassé M, El Saghir J, Berthier CC, Eddy S, Fischer M, Laufer SD, Kylies D, Hutzfeldt A, Bonin LL, Dumoulin B, Menon R, Vega-Warner V, Eichinger F, Alakwaa F, Fermin D, Billing AM, Minakawa A, McCown PJ, Rose MP, Godfrey B, Meister E, Wiech T, Noriega M, Chrysopoulou M, Brandts P, Ju W, Reinhard L, Hoxha E, Grahammer F, Lindenmeyer MT, Huber TB, Schlüter H, Thiel S, Mariani LH, Puelles VG, Braun F, Kretzler M, Demir F, Harder JL, Rinschen MM.
Nat Commun. 2023 Aug
The CCR6/CCL20 axis expands RORγt+ Tregs to protect from glomerulonephritis.
Georg R Herrnstadt, Christoph B Niehus, Torben Ramcke , Julia Hagenstein, Laura-Isabell Ehnold, Anna Nosko, Matthias T Warkotsch, Frederic C Feindt, Simon Melderis, Hans-Joachim Paust, Varshi Sivayoganathan, Saskia-Larissa Jauch-Speer, Milagros N Wong, Daniela Indenbirken, Christian F Krebs, Tobias B Huber, Ulf Panzer, Victor G Puelles, Malte A Kluger, Oliver M Steinmetz.
Kidney Int. 2023 Mar
CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12.
Hans-Joachim Paust, Ning Song, Donatella De Feo, Nariaki Asada, Selma Tuzlak, Yu Zhao, Jan-Hendrik Riedel, Malte Hellmig, Amirrtavarshni Sivayoganathan, Anett Peters, Anna Kaffke, Alina Borchers, Ulrich O Wenzel, Oliver M Steinmetz, Gisa Tiegs, Elisabeth Meister, Matthias Mack, Christian Kurts, Sibylle von Vietinghoff, Maja T Lindenmeyer, Elion Hoxha, Rolf A K Stahl, Tobias B Huber, Stefan Bonn, Catherine Meyer-Schwesinger, Thorsten Wiech, Jan-Eric Turner, Burkhard Becher, Christian F Krebs, Ulf Panzer
Sci Transl Med. 2023 Mar
Pathogenicity of Human Anti-PLA 2 R1 Antibodies in Minipigs: A Pilot Study.
Linda Reinhard, Thorsten Wiech, Aline Reitmeier, Moritz Lassé, Maya Machalitza, Asmus Heumann, Nicoletta Ferru, Desiree Loreth, Marie-Luise Schröder, Arvid Hutzfeldt, Felix R Stahl, Sven Peine, Hermann-Josef Gröne, Catherine Meyer-Schwesinger, Markus M Rinschen, Rolf A K Stahl, Elion Hoxha
J Am Soc Nephrol. 2023 Mar
False positivity for PLA2R1 antibody measured by ELISA in a nephrotic patient with no membranous nephropathy.
Elion Hoxha, Linda Reinhard, Thomas Castedello, Jan U Becker
Kidney Int. 2023 Feb
The classical pathway triggers pathogenic complement activation in membranous nephropathy.
Larissa Seifert, Gunther Zahner, Catherine Meyer-Schwesinger, Naemi Hickstein, Silke Dehde, Sonia Wulf, Sarah M S Köllner, Renke Lucas, Dominik Kylies, Sarah Froembling, Stephanie Zielinski, Oliver Kretz, Anna Borodovsky, Sergey Biniaminov, Yanyan Wang, Hong Cheng, Friedrich Koch-Nolte, Peter F Zipfel, Helmut Hopfer, Victor G Puelles, Ulf Panzer, Tobias B Huber, Thorsten Wiech, Nicola M Tomas
Nat Commun. 2023 Jan
Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury.
Jan-Hendrik Riedel, Lennart Robben, Hans-Joachim Paust, Yu Zhao, Nariaki Asada, Ning Song, Anett Peters, Anna Kaffke, Alina Borchers, Gisa Tiegs, Larissa Seifert, Nicola M Tomas, Elion Hoxha, Ulrich O Wenzel, Tobias B Huber, Thorsten Wiech, Jan-Eric Turner, Christian F Krebs, Ulf Panzer
JCI Insight. 2023 Jan
Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
Bertram T, Reimers D, Lory NC, Schmidt C, Schmid J, C Heinig L, Bradtke P, Rattay G, Zielinski S, Hellmig M, Bartsch P, Rohde H, Nuñez S, Rosemblatt MV, Bono MR, Gagliani N, Sandrock I, Panzer U, Krebs CF, Meyer-Schwesinger C, Prinz I, Mittrücker HW
Proc Natl Acad Sci U S A. 2023 Jan
The classical pathway triggers pathogenic complement activation in membranous nephropathy.
Larissa Seifert, Gunther Zahner, Catherine Meyer-Schwesinger, Naemi Hickstein, Silke Dehde, Sonia Wulf, Sarah M S Köllner, Renke Lucas, Dominik Kylies, Sarah Froembling, Stephanie Zielinski, Oliver Kretz, Anna Borodovsky, Sergey Biniaminov, Yanyan Wang, Hong Cheng, Friedrich Koch-Nolte, Peter F Zipfel, Helmut Hopfer, Victor G Puelles, Ulf Panzer, Tobias B Huber, Thorsten Wiech, Nicola M Tomas.
Nat Commun. 2023 Jan
The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice.
Mühlig AK, Steingröver J, Heidelbach HS, Wingerath M, Sachs W, Hermans-Borgmeyer I, Meyer-Schwesinger C, Choi HY, Lim BJ, Patry C, Hoffmann GF, Endlich N, Bracke K, Weiß M, Guse AH, Lassé M, Rinschen MM, Braun F, Huber TB, Puelles VG, Schmitt CP, Oh J.
Kidney Int. 2022 Jun
A protective role for Drosophila Filamin in nephrocytes via Yorkie mediated hypertrophy.
Koehler S, Huber TB, Denholm B.
Life Sci Alliance. 2022 Aug
Tissue-resident memory T cells in the kidney
Asada N, Ginsberg P, Gagliani N, Mittrücker HW, Panzer U.
Semin Immunopathol. 2022 Nov
Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs
Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Andreas Pannek, Thilo Albert, Chrystel Flores, Frank A Schildberg, Paul A Gleeson, Birgit M Reipert, Johannes Oldenburg, Christian Kurts
J Clin Invest. 2022 Nov
Bacterial infection possibly causing autoimmunity: Tropheryma whipplei and membranous nephropathy.
Thorsten Wiech, Linda Reinhard, Sonia Wulf, Alfio Edoardo Giuffrida, Elisa Longhitano, Rosario Caruso, Hermann-Josef Gröne, Rolf A K Stahl, Peter F Zipfel, Judith Kikhney, Annette Moter, Elion Hoxha, Domenico Santoro
Lancet. 2022 Nov
A slit-diaphragm-associated protein network for dynamic control of renal filtration.
Maciej K Kocylowski, Hande Aypek, Wolfgang Bildl, Martin Helmstädter, Philipp Trachte, Bernhard Dumoulin, Sina Wittösch, Lukas Kühne, Ute Aukschun, Carolin Teetzen, Oliver Kretz, Botond Gaal, Akos Kulik, Corinne Antignac, Geraldine Mollet, Anna Köttgen, Burulca Göcmen, Jochen Schwenk, Uwe Schulte, Tobias B Huber, Bernd Fakler, Florian Grahammer
Nat Commun. 2022 Oct
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.
Nina Kessler, Susanne F Viehmann, Calvin Krollmann, Karola Mai, Katharina M Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M C Böhner, Dennis Huugen, Carina C de Oliveira Mann, Simon Otten, Stefanie A I Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A Lyons, Peter Boor, Angela Rösen-Wolff, Lino L Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
J Exp Med. 2022 Oct
Netrin G1 Is a Novel Target Antigen in Primary Membranous Nephropathy.
Linda Reinhard, Maya Machalitza, Thorsten Wiech, Hermann-Josef Gröne, Moritz Lassé, Markus M Rinschen, Nicoletta Ferru, Jan Hinrich Bräsen, Friederike Drömann, Peter Maria Rob, Sanjeev Sethi, Elion Hoxha, Rolf A K Stahl
J Am Soc Nephrol. 2022 Oct
Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice
Tomas NM, Dehde S, Meyer-Schwesinger C, Huang M, Hermans-Borgmeyer I, Maybaum J, Lucas R, von der Heide JL, Kretz O, Köllner SMS, Seifert L, Huber TB, Zahner G.
Kidney Int. 2022 Sep
Generation of an alpaca serum that induces immune-mediated crescentic glomerulonephritis in mice.
Ermanila Dhana, Daniela Klaus, Alexander Böhner, Florian Schmidt, Sibylle von Vietinghoff, Peter Boor, Sonja Djudjaj, Christian Kurts
J Immunol Methods. 2022 Aug
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.
Rinschen MM, Palygin O, El-Meanawy A, Domingo-Almenara X, Palermo A, Dissanayake LV, Golosova D, Schafroth MA, Guijas C, Demir F, Jaegers J, Gliozzi ML, Xue J, Hoehne M, Benzing T, Kok BP, Saez E, Bleich M, Himmerkus N, Weisz OA, Cravatt BF, Krüger M, Benton HP, Siuzdak G, Staruschenko A.
Nat Commun. 2022 Jul