Publikationen
A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.
Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB.
Cell Rep. 2018 May
FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.
Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PF
J Immunol. 2018 Apr
Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity.
Menzel S, Schwarz N, Haag F, Koch-Nolte F.
Front Pharmacol. 2018 Mar
Tissue-Resident Lymphocytes in the Kidney.
Jan-Eric Turner, Martina Becker, Hans-Willi Mittrücker, Ulf Panzer
J Am Soc Nephrol. 2018 Feb
Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney
Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger C
Kidney Int. 2018 Jan
Host DNases prevent vascular occlusion by neutrophil extracellular traps.
Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TA
Science. 2017 Dec
Pro-longed IKKβ inhibition improves ongoing CTL antitumor responses by incapacitating regulatory T cells.
Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges JF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine AK, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.
Cell Rep. 2017 Oct
Natural killers: the bad guys in fibrosis?
Turner JE
Kidney Int. 2017 Jul
IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis
Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JE
J Am Soc Nephrol. 2017 Jul
RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.
Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.
Clin Exp Immunol. 2017 Apr
A pathogenic role of complement in arterial hypertension and hypertensive end organ damage.
Wenzel UO, Bode M, Köhl J, Ehmke H
Am J Physiol Heart Circ Physiol. 2017 Mar
Fully automated evaluation of total glomerular num-ber and capillary tuft size in murine nephritic kidneys using lightsheet microscopy.
Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Matthias Gunzer
J Am Soc Nephrol. 2017 Feb
T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN.
Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM
J Am Soc Nephrol. 2017 Jan
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.
Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F
Sci Transl Med. 2016 Nov
Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney.
Christian F Krebs, Hans-Joachim Paust, Sonja Krohn, Tobias Koyro, Silke R Brix, Jan-Hendrik Riedel, Patricia Bartsch, Thorsten Wiech, Catherine Meyer-Schwesinger, Jiabin Huang, Nicole Fischer, Philipp Busch, Hans-Willi Mittrücker, Ulrich Steinhoff, Brigitta Stockinger, Laura Garcia Perez , Ulrich O Wenzel, Matthias Janneck, Oliver M Steinmetz, Nicola Gagliani, Rolf A K Stahl, Samuel Huber, Jan-Eric Turner, Ulf Panzer
Immunity. 2016 Nov
Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.
Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RAK, Panzer U, Steinmetz OM.
Kidney Int. 2016 Jan
A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.
Penelope Pelczar, Mario Witkowski, Laura Garcia Perez, Jan Kempski, Anna G Hammel, Leonie Brockmann, Dörte Kleinschmidt, Sandra Wende, Cathleen Haueis, Tanja Bedke, Marco Witkowski, Susanne Krasemann, Stefan Steurer, Carmen J Booth, Philipp Busch, Alexandra König, Ursula Rauch, Daniel Benten, Jakob R Izbicki, Thomas Rösch, Ansgar W Lohse, Till Strowig, Nicola Gagliani, Richard A Flavell, Samuel Huber
Science. 2016 Oct
Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Ag-gravates the Progression of crescentic glomerulonephritis.
Gotot J, Piotrowski E, Otte MS, Tittel AP, Guo L, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss F
J Am Soc Nephrol. 2016 Jul
FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.
Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C
J Immunol. 2016 Jul
A NLRP3-specific inflammasome inhibitor potently attenuates crystal-induced kidney fibrosis in vivo.
Ludwig-Portugall I,*, Bartok E,* Dhana E, Evers BDG, Primiano MJ, Hall PJ, Franklin BS, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.
Kidney Int 2016